OROTIC ACID BUTYL ESTER

Base Information

• Chemical Name: OROTIC ACID BUTYL ESTER
• CAS No.: 22754-37-6
• Molecular Formula: C9H12N2O4
• Molecular Weight: 212.205
• Hs Code.: 2933599090
• Mol file: 22754-37-6.mol

Synonyms:Orotic acid, butyl ester (6CI,7CI,8CI);NSC 32774;

Chemical Property of OROTIC ACID BUTYL ESTER

Chemical Property:

• Refractive Index: 1.498
• PSA: 92.02000
• Density: 1.248g/cm³
• LogP: 0.02010

Purity/Quality:

98%min ^*data from raw suppliers

OROTIC ACID BUTYL ESTER 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of OROTIC ACID BUTYL ESTER

There total 2 articles about OROTIC ACID BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

orotic acid (65-86-1,58915-47-2,6784-70-9) + butan-1-ol (71-36-3) → butyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate (22754-37-6)

Guidance literature:

With sulfuric acid; for 12h; Reflux;

DOI:10.1021/acs.jmedchem.9b01339

Reference yield:

→ butyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate (22754-37-6)

Guidance literature:

Orotsaeure, Butanol-(1), konz. H2SO4, Siedetemp., 6h;

DOI:10.1021/jo01081a031

Reference yield: 45.0%

butyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate (22754-37-6) → Orotic acid hydrazide (26409-12-1,26696-56-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1515/chem-2020-0096

upstream raw materials:

orotic acid

butan-1-ol

Downstream raw materials:

Metyl Ester of 6-Piperidino-2-(carbethoxy)methylthiopyrimidine-4-carboxylic acid

1,3-bis-(4-methoxy-benzyl)-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid butyl ester

Orotic acid hydrazide

Refernces

• 1、 Al-Obaid, Abdulrahman M.,Alfayez, Musaad,Bari, Ahmed,Betz, Richard,Ghadeer, Abdulrahman,Hosten, Eric C.,Mahmood, Amer,Syed, Saeed Ali. "Synthesis of orotic acid derivatives and their effects on stem cell proliferation". . p. 620 - 627. Retrieved 2020/07/20.