N-(2-Benzoyl-4-chlorophenyl)formamide

Base Information

• Chemical Name: N-(2-Benzoyl-4-chlorophenyl)formamide
• CAS No.: 10352-28-0
• Molecular Formula: C14H10 Cl N O2
• Molecular Weight: 259.692
• Hs Code.: 2924299090
• European Community (EC) Number: 233-767-7
• NSC Number: 338521
• UNII: T620ANU9VW
• DSSTox Substance ID: DTXSID20145886
• Nikkaji Number: J22.477D
• Wikidata: Q83010573
• Mol file: 10352-28-0.mol

Synonyms:N-(2-Benzoyl-4-chlorophenyl)formamide;10352-28-0;5-chloro-2-formamidobenzophenone;Formamido chlorobenzophenone;T620ANU9VW;EINECS 233-767-7;NSC-338521;NSC338521;UNII-T620ANU9VW;SCHEMBL11457524;2'-benzoyl-4'-chloroformanilide;DTXSID20145886;5-Chloro-2-(formylamino)benzophenone;NSC 338521;Formamide, N-(2-benzoyl-4-chlorophenyl)-;FT-0757994;N-(2-BENZOYL-4-CHLOROPHENYL) FORMAMIDE;FORMAMIDO CHLOROBENZOPHENONE [USP IMPURITY];(4R-Cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester

Chemical Property of N-(2-Benzoyl-4-chlorophenyl)formamide

Chemical Property:

• Vapor Pressure: 2.74E-10mmHg at 25°C
• Melting Point: 89 °C
• Boiling Point: 504.1°C at 760 mmHg
• PKA: 13.54±0.70(Predicted)
• Flash Point: 258.7°C
• PSA: 46.17000
• Density: 1.323g/cm³
• LogP: 3.84820
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 259.0400063
• Heavy Atom Count: 18
• Complexity: 302

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(2-Benzoyl-4-chlorophenyl)formamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=C(C=CC(=C2)Cl)NC=O
• Uses: N-(2-Benzoyl-4-chlorophenyl)formamide is used as a reagent in the synthesis of 2-aminoindole compounds that can be used as antimalarial agents.

Technology Process of N-(2-Benzoyl-4-chlorophenyl)formamide

There total 7 articles about N-(2-Benzoyl-4-chlorophenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-chloro-2-aminobenzophenone (719-59-5) → N-(2-benzoyl-4-chlorophenyl)formamide (10352-28-0)

Guidance literature:

With sodium hydrogencarbonate; In formic acid; water; ethyl acetate;

Reference yield: 90.0%

formic acid (64-18-6) + 5-chloro-2-aminobenzophenone (719-59-5) → N-(2-benzoyl-4-chlorophenyl)formamide (10352-28-0)

Guidance literature:

at 117 ℃; for 24h; Reflux; Inert atmosphere;

Reference yield: 75.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + 5-chloro-2-aminobenzophenone (719-59-5) → N-(2-benzoyl-4-chlorophenyl)formamide (10352-28-0)

Guidance literature:

With tert.-butylhydroperoxide; In water; at 90 ℃; for 16h;

DOI:10.1002/adsc.201800783

upstream raw materials:

formic acid

5-chloro-2-aminobenzophenone

formyl acetic anhydride

phenylmagnesium bromide

Downstream raw materials:

6-Chlor-3-(4-chlorphenyl)-3,4-dihydro-4-hydroxy-4-phenylchinazolin

N-[4-Chloro-2-((E)-1-hydroxy-1,3-diphenyl-allyl)-phenyl]-formamide

(5-chloro-2-isocyanophenyl)(phenyl)methanone

6-chloro-4-phenyl-2-(piperidin-1-yl)quinoline

Refernces

• 1、 Gao, Yuelei,Hu, Zhongyan,Dong, Jinhuan,Liu, Jun,Xu, Xianxiu. "Chemoselective double annulation of two different isocyanides: Rapid access to trifluoromethylated indole-fused heterocycles". supporting information. p. 5292 - 5295. Retrieved 2017/11/06.
• 2、 Kobayashi, Kazuhiro,Yoneda, Keiichi,Miyamoto, Kazuna,Morikawa, Osamu,Konishi, Hisatoshi. "A convenient synthesis of quinolines by reactions of o-isocyano-β- methoxystyrenes with nucleophiles". . p. 11639 - 11645. Retrieved 2007/10/03.