Carbamic acid, [5-[[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]amino]hexyl]-, phenylmethyl ester, monohydrochloride

Base Information

• Chemical Name: Carbamic acid, [5-[[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]amino]hexyl]-, phenylmethyl ester, monohydrochloride
• CAS No.: 88719-61-3
• Molecular Formula: C22H30N2O5.ClH
• Molecular Weight: 438.952
• Mol file: 88719-61-3.mol

Synonyms:

Chemical Property of Carbamic acid, [5-[[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]amino]hexyl]-, phenylmethyl ester, monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [5-[[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]amino]hexyl]-, phenylmethyl ester, monohydrochloride

There total 3 articles about Carbamic acid, [5-[[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]amino]hexyl]-, phenylmethyl ester, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

(5-oxo-hexyl)-carbamic acid benzyl ester (95484-19-8) + norepinephrine hydrochloride (55-27-6) → {5-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-hexyl}-carbamic acid benzyl ester; hydrochloride (88719-61-3)

Guidance literature:

With sodium cyanoborohydride; In methanol; at 50 ℃;

DOI:10.1021/jm50001a017

Reference yield:

6-oxoheptanoic acid (3128-07-2) → {5-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-hexyl}-carbamic acid benzyl ester; hydrochloride (88719-61-3)

Guidance literature:

Multi-step reaction with 3 steps

1: diphenylphosphoryl azide (DPPA), triethylamine / benzene / 1.) 23 deg C, 30 min, 2.) reflux, 15 min

2: benzene / 17 h / Heating

3: 32 percent / NaCNBH₄ / methanol / 50 °C

With diphenylphosphoranyl azide; sodium cyanoborohydride; triethylamine; In methanol; benzene;

DOI:10.1021/jm50001a017

Reference yield:

6-Isocyanato-hexan-2-one (70486-31-6) → {5-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-hexyl}-carbamic acid benzyl ester; hydrochloride (88719-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 17 h / Heating

2: 32 percent / NaCNBH₄ / methanol / 50 °C

With sodium cyanoborohydride; In methanol; benzene;

DOI:10.1021/jm50001a017

upstream raw materials:

(5-oxo-hexyl)-carbamic acid benzyl ester

norepinephrine hydrochloride

6-oxoheptanoic acid

6-Isocyanato-hexan-2-one

Downstream raw materials:

4-[2-(5-Amino-1-methyl-pentylamino)-1-hydroxy-ethyl]-benzene-1,2-diol; hydrochloride

Refernces