[2-(3,4-Dihydroxyphenyl)-2-hydroxyethyl]azanium;chloride

Base Information

• Chemical Name: [2-(3,4-Dihydroxyphenyl)-2-hydroxyethyl]azanium;chloride
• CAS No.: 55-27-6
• Molecular Formula: C8H11 N O3 . Cl H
• Molecular Weight: 205.641
• Hs Code.: 2922509090
• Mol file: 55-27-6.mol

Synonyms:BENZYL ALCOHOL, alpha-(AMINOMETHYL)-3,4-DIHYDROXY-, HYDROCHLORIDE, (-)-;L-alpha-(Aminomethyl)-3,4-dihydroxybenzyl alcohol hydrochloride;LS-42679

Chemical Property of [2-(3,4-Dihydroxyphenyl)-2-hydroxyethyl]azanium;chloride

Chemical Property:

• Vapor Pressure: 1.3E-08mmHg at 25°C
• Melting Point: 140-144 °C (dec.)
• Boiling Point: 442.6°Cat760mmHg
• Flash Point: 221.5°C
• PSA: 86.71000
• Density: 1.397g/cm³
• LogP: 1.59220
• Storage Temp.: 2-8°C
• Solubility.: water: soluble50mg/mL, clear to slightly hazy, faintly yellow to
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 205.0505709
• Heavy Atom Count: 13
• Complexity: 142

Purity/Quality:

99% ^*data from raw suppliers

DL-Norepinephrine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1C(C[NH3+])O)O)O.[Cl-]
• Uses: DL-Norepinephrine hydrochloride is suitable adrenergic drug used in the following studies:To investigate the effects of adrenergic drugs on lantern of larval fly.To evaluate the ability of α-adrenergic stimulation in the presence of elevated calcium levels to induce delayed after depolarizations and triggered activity in Purkinje fibers isolated from cat hearts.Simultaneous reduction and surface functionalization of graphene oxide by a one-step poly(norepinephrine) functionalization.

Technology Process of [2-(3,4-Dihydroxyphenyl)-2-hydroxyethyl]azanium;chloride

There total 3 articles about [2-(3,4-Dihydroxyphenyl)-2-hydroxyethyl]azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 2-(3,4-dihydroxyphenyl)-2-hydroxyethylcarbamate (1207201-66-8) → norepinephrine hydrochloride (55-27-6)

Guidance literature:

With methanol; chloro-trimethyl-silane; for 3h; Reflux;

DOI:10.1055/s-0029-1217027

Reference yield: 96.7%

1-(3,4-dihydroxyphenyl)-1-oxo-2-amino-ethan-hydrochlorid (5090-29-9) → norepinephrine hydrochloride (55-27-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 45 ℃; for 5h; under 0.30003 - 0.375038 Torr; Temperature; Pressure; Time;

Reference yield:

C8H11NO3*C7H8N2O*2ClH → norepinephrine hydrochloride (55-27-6) + N-methylnicotinamide hydrochloride (29711-57-7)

Guidance literature:

at 28 ℃; Equilibrium constant; Thermodynamic data; association enthalpy: ΔH⁰ (kcal mol^-1) = -3.8 (pH=1);

DOI:10.1016/0223-5234(89)90014-7

upstream raw materials:

tert-butyl 2-(3,4-dihydroxyphenyl)-2-hydroxyethylcarbamate

1-(3,4-dihydroxyphenyl)-1-oxo-2-amino-ethan-hydrochlorid

Downstream raw materials:

{4-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-pentyl}-carbamic acid benzyl ester; hydrochloride

{5-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-hexyl}-carbamic acid benzyl ester; hydrochloride

STO 41424

N-<5-<<(cyclohexylamino)carbonyl>oxy>-2-pentyl>norepinephrine

Refernces

• 1、 Bernini, Roberta,Crisante, Fernanda,Barontini, Maurizio,Fabrizi, Giancarlo. "A new and efficient route for the synthesis of naturally occurring catecholamines". experimental part. p. 3838 - 3842. Retrieved 2010/03/30.