N-Formyl-DL-methionine

Base Information

• Chemical Name: N-Formyl-DL-methionine
• CAS No.: 4309-82-4
• Molecular Formula: C6H11NO3S
• Molecular Weight: 177.224
• Hs Code.: 2930909090
• European Community (EC) Number: 224-322-8
• NSC Number: 334322,206506
• Wikipedia: N-Formylmethionine
• Wikidata: Q307455
• Mol file: 4309-82-4.mol

Synonyms:N-Formyl-DL-methionine;For-DL-Met-OH;4309-82-4;2-formamido-4-methylsulfanylbutanoic acid;(2S)-2-formamido-4-methylsulfanylbutanoic acid;EINECS 224-322-8;N-Formyl methionine;N-Formyl(methyl)homocysteine #;NSC-334322;Formyl-DL-methionine;Methionine,N-formyl-;DL-Methionine, N-formyl-;SCHEMBL38594;CHEBI:182822;MFCD00063284;NSC206506;NSC334322;AKOS009159215;NSC 206506;NSC-206506;2-ormamido-4-methylsulanylbutanoic acid;AS-56515;2-Formylamino-4-methylsulfanyl-butyric acid;Butanoic acid, 2-formylamino-4-methylthio-;CS-0188321;F0123;FT-0657668;FT-0659115;Q307455

Chemical Property of N-Formyl-DL-methionine

Chemical Property:

• Melting Point: 103 °C
• Boiling Point: 453.5 °C at 760 mmHg
• Flash Point: 228.1 °C
• PSA: 91.70000
• Density: 1.242 g/cm³
• LogP: 0.96550
• Storage Temp.: −20°C
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 177.04596439
• Heavy Atom Count: 11
• Complexity: 140

Purity/Quality:

99.5% ^*data from raw suppliers

Formyl-L-methionine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CSCCC(C(=O)O)NC=O

Technology Process of N-Formyl-DL-methionine

There total 3 articles about N-Formyl-DL-methionine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

formic acid (64-18-6) + DL-methionine (59-51-8,26062-47-5,58576-49-1) → 2-formylamino-4-(methylthio)butanoic acid (4309-82-4)

Guidance literature:

In N,N-dimethyl-formamide; for 0.25h; Heating;

Reference yield:

N-[1-(Benzoimidazole-1-carbonyl)-3-methylsulfanyl-propyl]-formamide (93033-05-7) → 2-formylamino-4-(methylthio)butanoic acid (4309-82-4)

Guidance literature:

In tetrahydrofuran; water; at 22 ℃; Kinetics;

Reference yield:

→ 2-formylamino-4-(methylthio)butanoic acid (4309-82-4)

Guidance literature:

Methionin, HCOOH, wenig Ac2O;

upstream raw materials:

formic acid

DL-methionine

N-[1-(Benzoimidazole-1-carbonyl)-3-methylsulfanyl-propyl]-formamide

Downstream raw materials:

N-(N-Formyl-DL-methionyl)-N',N'-bis-(2-chlor-aethyl)-p-phenylendiamin

L-methionine

N-formyl-D-methionine

D-methionine

Refernces

• 1、 -. "Palatability of aquaculture feed". . . Retrieved 2008/06/13.
• 2、 Aizpurua, Jezus Mari,Palomo, Claudio. "REAGENTS AND SYNTHETIC METHODS. 30. PRACTICAL AND IMPROVED METHOD FOR FORMYLATING AMINO COMPOUNDS BY MEANS OF FORMIC ACID-DIMETHYLFORMAMIDE SYSTEM.". . p. 745 - 752. Retrieved 2007/10/02.