4-chlorophenyl dimethylcarbamate

Base Information

• Chemical Name: 4-chlorophenyl dimethylcarbamate
• CAS No.: 7305-03-5
• Molecular Formula: C9H10 Cl N O2
• Molecular Weight: 199.637
• Mol file: 7305-03-5.mol

Synonyms:Carbamicacid, dimethyl-, p-chlorophenyl ester (6CI,7CI,8CI); 4-ChlorophenylN,N-dimethylcarbamate; NSC 505498; p-Chlorophenyl N,N-dimethylcarbamate;p-Chlorophenyl dimethylcarbamate

Chemical Property of 4-chlorophenyl dimethylcarbamate

Chemical Property:

• Vapor Pressure: 0.00665mmHg at 25°C
• Boiling Point: 270.9°Cat760mmHg
• Flash Point: 117.6°C
• Density: 1.226g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chlorophenyl dimethylcarbamate

There total 5 articles about 4-chlorophenyl dimethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-chloro-phenol (106-48-9,82344-39-6) + N,N-Dimethylcarbamoyl chloride (79-44-7) → O-(4-chlorophenyl)-N,N-dimethylcarbamate (7305-03-5)

Guidance literature:

4-chloro-phenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 5 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

N,N-Dimethylcarbamoyl chloride; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.0c00831

Reference yield: 81.0%

4-chloro-phenol (106-48-9,82344-39-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → O-(4-chlorophenyl)-N,N-dimethylcarbamate (7305-03-5)

Guidance literature:

With tert.-butylhydroperoxide; 1,10-Phenanthroline; copper diacetate; In decane; at 80 ℃; for 8h;

DOI:10.1055/s-0034-1378519

Reference yield:

bis(4-chlorophenyl) carbonate (2167-53-5) → O-(4-chlorophenyl)-N,N-dimethylcarbamate (7305-03-5)

Guidance literature:

With water; dimethyl amine;

upstream raw materials:

bis(4-chlorophenyl) carbonate

4-chloro-phenol

N,N-Dimethylcarbamoyl chloride

N,N-dimethyl-formamide

Downstream raw materials:

4-chloro-2-hydroxyphenyl dimethylcarbamate

4-chloro-2-(thiophene-2-carbonyl)phenyl dimethylcarbamate

2-(2-naphthoyl)-4-chlorophenyl dimethylcarbamate

2-(4-bromobenzoyl)-4-chlorophenyl dimethylcarbamate

Refernces

• 1、 Sun, Xiuyun,Yao, Xia,Zhang, Chao,Rao, Yu. "Pd(II) catalyzed ortho C-H iodination of phenylcarbamates at room temperature using cyclic hypervalent iodine reagents". supporting information. p. 10014 - 10017. Retrieved 2015/06/22.
• 2、 Reddy, Nagireddy Veera,Kumar, Gadde Sathish,Kumar, Pailla Santhosh,Kantam, M. Lakshmi,Reddy, Kallu Rajender. "Ligand-assisted copper-catalyzed oxidative cross-coupling of simple phenols with formamides for the synthesis of carbamates". supporting information. p. 2133 - 2138. Retrieved 2014/11/08.