2-Amino-7-bromofluorene

Base Information

• Chemical Name: 2-Amino-7-bromofluorene
• CAS No.: 6638-60-4
• Molecular Formula: C13H10BrN
• Molecular Weight: 260.133
• Hs Code.: 2921499090
• European Community (EC) Number: 625-606-8
• NSC Number: 48265
• UNII: A38TF5YTF4
• DSSTox Substance ID: DTXSID20216601
• Nikkaji Number: J308.964I
• Wikidata: Q72438559
• Mol file: 6638-60-4.mol

Synonyms:2-Amino-7-bromofluorene;7-Bromo-9H-fluoren-2-amine;6638-60-4;2-Bromo-7-aminofluorene;FLUOREN-2-AMINE, 7-BROMO-;C13H10BrN;NSC 48265;BRN 2805053;A38TF5YTF4;7-Bromo-9H-fluoren-2-ylamine;NSC-48265;NSC48265;UNII-A38TF5YTF4;SCHEMBL666531;2-Amino-7-bromo-9H-fluorene;C13-H10-Br-N;2-Amino-7-bromofluorene, 90%;7-bromo-9H-fluoren-2-y-lamine;7-bromo-9H-fluoren-2-yl-amine;7-Bromo-9H-fluoren-2-amine #;DTXSID20216601;MFCD00001127;AKOS015915032;AC-5817;BP-12744;LS-69163;CS-0017978;FT-0636215;H10919;A835443;J-508494

Chemical Property of 2-Amino-7-bromofluorene

Chemical Property:

• Appearance/Colour: similar to white powder
• Vapor Pressure: 1.16E-07mmHg at 25°C
• Melting Point: 148-149 ºC
• Refractive Index: 1.717
• Boiling Point: 431.9 °C at 760 mmHg
• PKA: 3.90±0.20(Predicted)
• Flash Point: 215 °C
• PSA: 26.02000
• Density: 1.559 g/cm³
• LogP: 4.18370
• Water Solubility.: Sparingly soluble in water. (0.724 mg/L)
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 258.99966
• Heavy Atom Count: 15
• Complexity: 243

Purity/Quality:

98%, ^*data from raw suppliers

2-Amino-7-bromofluorene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Polycyclic Aromatic Hydrocarbons
• Canonical SMILES: C1C2=C(C=CC(=C2)N)C3=C1C=C(C=C3)Br
• Uses: It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Technology Process of 2-Amino-7-bromofluorene

There total 10 articles about 2-Amino-7-bromofluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-bromo-7-nitro-9H-fluorene (6638-61-5) → 2-amino-7-bromofluorene (6638-60-4)

Guidance literature:

With hydrogenchloride; tin(II) chloride dihdyrate; In ethanol; water; at 80 ℃; for 3.5h;

Reference yield: 81.0%

2-aminofluorene (153-78-6) → 2-amino-7-bromofluorene (6638-60-4)

Guidance literature:

With N-Bromosuccinimide; In acetone; at 60 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tetlet.2021.153494

Reference yield:

(2-bromo-5-nitro-phenyl)methanol (332883-48-4) → 2-amino-7-bromofluorene (6638-60-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Pd(OAc)2; Tol₃P / dioxane

2: polyphosphoric acid / 110 °C

3: H₂ / PtO₂ / methanol; tetrahydrofuran

With palladium diacetate; PPA; hydrogen; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1016/j.bmcl.2005.08.003

upstream raw materials:

2-bromo-7-nitro-9H-fluorene

2,9-dibromo-7-nitro-fluorene

ammonia

(2-bromo-5-nitro-phenyl)methanol

Refernces

• 1、 -. "A N, N - diaryl - 2 - bromo - 6 - naphthylamine synthetic method and its application". Paragraph 0109; 0110; 0137; 0138. . Retrieved 2017/12/01.
• 2、 -. "Liquid crystal materials and devices". . . Retrieved 2008/06/13.