Thieno[2,3-c]pyridine

Base Information

• Chemical Name: Thieno[2,3-c]pyridine
• CAS No.: 272-12-8
• Molecular Formula: C7H5NS
• Molecular Weight: 135.1863
• Hs Code.: 2934999090
• European Community (EC) Number: 820-521-4
• NSC Number: 152396
• UNII: C2A49UZQ9T
• DSSTox Substance ID: DTXSID60181662
• Nikkaji Number: J119.539E
• Wikidata: Q83052290
• Mol file: 272-12-8.mol

Synonyms:Thieno[2,3-c]pyridine;272-12-8;Thieno(2,3-c)pyridine;6-Azabenzo[b]thiophene;6-AZATHIANAPHTHENE;MFCD01760492;NSC-152396;NSC152396;thieno[2,3-c]-pyridine;C2A49UZQ9T;SCHEMBL10970;DTXSID60181662;AKOS006341649;DS-1715;MB02036;NSC 152396;PS-4157;SB36316;ACETYLPHOSPHATELITHIUMPOTASSIUMSALT;SY028707;LS-152394;CS-0006104;FT-0685440;EN300-233967;A877001;J-016693;J-524930

Chemical Property of Thieno[2,3-c]pyridine

Chemical Property:

• Vapor Pressure: 0.0266mmHg at 25°C
• Melting Point: 58℃
• Refractive Index: 1.689
• Boiling Point: 255.1 °C at 760 mmHg
• PKA: 4.74±0.30(Predicted)
• Flash Point: 112.3 °C
• PSA: 41.13000
• Density: 1.272 g/cm³
• LogP: 2.29630
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 135.01427034
• Heavy Atom Count: 9
• Complexity: 105

Purity/Quality:

99% ^*data from raw suppliers

Thieno[2,3-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC2=C1C=CS2

Technology Process of Thieno[2,3-c]pyridine

There total 18 articles about Thieno[2,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

→ thieno[2,3-c]-pyridine (272-12-8)

Guidance literature:

Reference yield: 58.0%

N-(2,2-dimethoxyethyl)-4-methyl-N-(thiophen-2-ylmethyl)benzenesulfonamide (58754-98-6) → thieno[2,3-c]-pyridine (272-12-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1107/S0108270197002084

Reference yield: 46.0%

C10H10N2O2S (74301-92-1) → thieno[2,3-c]-pyridine (272-12-8) + Thieno[2,3-c]pyridin-7-yl-carbamic acid ethyl ester (79179-95-6)

Guidance literature:

Irradiation;

DOI:10.1248/cpb.29.1539

upstream raw materials:

4-ethyl-pyridine-3-thiol

(2,2-diethoxy-ethyl)-thiophen-2-ylmethylene-amine

thieno[2,3-c]pyridine-5-carboxylic acid

C₁₀H₁₀N₂O₂S

Downstream raw materials:

1,3-Diphenyl-1,9b-dihydro-thieno[2,3-c][1,2,4]triazolo[4,3-a]pyridine

1-(4-Nitro-phenyl)-3-phenyl-1,9b-dihydro-thieno[2,3-c][1,2,4]triazolo[4,3-a]pyridine

2,4,6-Trimethyl-benzenesulfonate6-amino-thieno[2,3-c]pyridin-6-ium;

3-(4-Methoxy-phenyl)-1-phenyl-1,9b-dihydro-thieno[2,3-c][1,2,4]triazolo[4,3-a]pyridine

Refernces

• 1、 -. "Therapeutic Pyrazolyl Thienopyridines". Page/Page column 22. . Retrieved 2008/06/13.
• 2、 Graulich, Amaury,Liegeois, Jean-Francois. "A rapid synthesis of thieno[2,3-c]pyridine and 2-substituted thieno[2,3-c]pyridines". . p. 1935 - 1937. Retrieved 2007/10/03.