58754-98-6

Basic information

• Product Name: N-(2,2-dimethoxyethyl)-4-methyl-N-(thiophen-2-ylmethyl)benzenesulfonamide
• CAS NO: 58754-98-6
• Molecular Formula: C₁₆H₂₁NO₄S₂
• Molecular Weight: 355.4722
• Mol File: 58754-98-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 485°C at 760 mmHg
• Flash Point: 247.1°C
• Density: 1.251g/cm³
• Vapor Pressure: 1.46E-09mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: N-(2,2-dimethoxyethyl)-4-methyl-N-(thiophen-2-ylmethyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,2-dimethoxyethyl)-4-methyl-N-(thiophen-2-ylmethyl)benzenesulfonamide(58754-98-6)
• EPA Substance Registry System: N-(2,2-dimethoxyethyl)-4-methyl-N-(thiophen-2-ylmethyl)benzenesulfonamide(58754-98-6)

Safety Data

• Hazardous Substances Data: 58754-98-6(Hazardous Substances Data)

Upstream product

• 55390-18-6 (2,2-Dimethoxy-ethyl)-[1-thiophen-2-yl-meth-(Z)-ylidene]-amine 
• 98-03-3 thiophene-2-carbaldehyde 
• 58754-99-7 dimethoxy-N-(thiophen-2-ylmethyl)ethanamine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 94226-19-4 thieno[3,2-c]pyridine-2-carbaldehyde 
• 272-14-0 thieno[3,2-c]pyridine 
• 272-12-8 thieno[2,3-c]-pyridine 

Relevant articles and documents

Design, synthesis, and antifibrosis evaluation of 4-(benzo-[c][1,2,5]thiadiazol-5-yl)-3(5)-(6-methyl- pyridin-2-yl)pyrazole and 3(5)-(6-methylpyridin- 2-yl)-4-(thieno-[3,2,-c]pyridin-2-yl)pyrazole derivatives

Six series of 4-(benzo[c][1,2,5]thiadiazol-5-yl)-3(5)-(6-methylpyridin-2-yl)- pyrazoles 18a–d, 19a–d, 22a–d and 3(5)-(6-methylpyridin-2-yl)-4-(thieno[3,2,-c]- pyridin-2-yl)pyrazoles 20a–d, 21a–d, 23c, 23d have been synthesized and evaluated for their activin receptor-like kinase 5 (ALK5) and p38α mitogen activated protein (MAP) kinase inhibitory activities in enzymatic assays. Among these compounds, the most active compound, 22c, inhibited ALK5 phosphorylation with an IC50 value of 0.030 μM in the enzymatic assay. Compound 22c showed four-fold more potent activity against ALK5 kinase than the clinical candidate, compound LY-2157299. The selectivity index of 22c against p38α MAP kinase is 235, which is much higher than that of LY-2157299 (4) and equally selective to that of EW-7197 (218). Compound 22c effectively suppressed protein and mRNA expression of collagen I and α-SMA in TGF-β-induced LX-2 human hepatic stellate cell (HSC), this result shows that compound 22c has the ability to inhibit the activation of HSC. Compound 22c is expected to be a preclinical candidate for the treatment of hepatic fibrosis.