272-12-8

Basic information

• Product Name: THIENO[2,3-C]PYRIDINE
• Synonyms: THIENO[2,3-C]PYRIDINE;6-Azathianaphthene;6-Azabenzo[b]thiophene;thieno[2;NSC 152396
• CAS NO: 272-12-8
• Molecular Formula: C₇H₅NS
• Molecular Weight: 135.19
• Product Categories: Building Blocks;Thieno[x,x-y]pyridine
• Mol File: 272-12-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 58℃
• Boiling Point: 68℃ (0.5 Torr)
• Flash Point: 112.3 °C
• Appearance: /
• Density: 1.272 g/cm³
• Vapor Pressure: 0.0266mmHg at 25°C
• Refractive Index: 1.689
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.74±0.30(Predicted)
• CAS DataBase Reference: THIENO[2,3-C]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: THIENO[2,3-C]PYRIDINE(272-12-8)
• EPA Substance Registry System: THIENO[2,3-C]PYRIDINE(272-12-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 272-12-8(Hazardous Substances Data)

Usage

General Description

Thieno[2,3-c]pyridine is a chemical compound with a fused ring structure consisting of a thiophene ring and a pyridine ring. It is also known as thienopyridine and is used as a building block in the synthesis of organic compounds and pharmaceuticals. Thieno[2,3-c]pyridine derivatives have been studied for their potential biological activities, including as anti-cancer agents, anti-inflammatory agents, and as inhibitors of protein kinases. Its unique structure and aromatic properties make it an important scaffold in medicinal chemistry for the development of new drug candidates. Additionally, thieno[2,3-c]pyridine compounds have also been explored for their potential use as materials in organic electronics and optoelectronic devices.

InChI:InChI=1/C7H5NS/c1-3-8-5-7-6(1)2-4-9-7/h1-5H

Upstream product

• 113825-04-0 (2,2-diethoxy-ethyl)-thiophen-2-ylmethylene-amine 
• 86119-84-8 phosphoric acid 
• 10025-87-3 trichlorophosphate 
• 7664-93-9 sulfuric acid 
• 60249-06-1 thieno[2,3-c]pyridine-5-carboxylic acid ethyl ester 
• 79180-12-4 2,4,6-Trimethyl-benzenesulfonate6-amino-thieno[2,3-c]pyridin-6-ium; 
• 58754-99-7 dimethoxy-N-(thiophen-2-ylmethyl)ethanamine 
• 98-03-3 thiophene-2-carbaldehyde 
• 55390-18-6 (2,2-Dimethoxy-ethyl)-[1-thiophen-2-yl-meth-(Z)-ylidene]-amine 
• 756477-25-5 {[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-thiophen-2-yl-methyl}-phosphonic acid dimethyl ester 
• 110-86-1 pyridine 
• 102000-77-1 4-ethyl-pyridine-3-thiol 
• 58754-98-6 N-(2,2-dimethoxyethyl)-4-methyl-N-(thiophen-2-ylmethyl)benzenesulfonamide 
• 74301-92-1 C₁₀H₁₀N₂O₂S 

Downstream Products

• 110071-79-9 1,3-Diphenyl-1,9b-dihydro-thieno[2,3-c][1,2,4]triazolo[4,3-a]pyridine 
• 110071-82-4 1-(4-Nitro-phenyl)-3-phenyl-1,9b-dihydro-thieno[2,3-c][1,2,4]triazolo[4,3-a]pyridine 
• 79180-12-4 2,4,6-Trimethyl-benzenesulfonate6-amino-thieno[2,3-c]pyridin-6-ium; 
• 110071-80-2 3-(4-Methoxy-phenyl)-1-phenyl-1,9b-dihydro-thieno[2,3-c][1,2,4]triazolo[4,3-a]pyridine 
• 93582-95-7 6-Benzoyl-7-cyano-6,7-dihydrothieno<2,3-c>pyridine 
• 203922-18-3 thieno[2,3-c]pyridine-2-carbaldehyde 
• 1402598-51-9 N-((2-methoxyphenyl)(thieno[2,3-c]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide 
• 1402598-46-2 N-((2-(methylsulfanyl)phenyl)(thieno[2,3-c]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide 
• 1402598-42-8 N-(phenyl(thieno[2,3-c]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide 
• 875415-18-2 1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-thieno[2,3-c]pyridin-2-ylmethylpentan-2-ol 
• 63326-75-0 thieno[2,3-c]pyridin-3-amine 
• 93612-34-1 3-Phenylpyrrolo<6,7-a>thieno<2,3-c>pyridine-2-carboxamide 
• 93582-98-0 6-Benzoyl-7-methyl-6,7-dihydro-thieno[2,3-c]pyridine-7-carbonitrile 
• 30434-07-2 7-styryl-thieno[2,3-c]pyridine 

Relevant articles and documents

Thieno[2,3-c]pyridine, the first structure of a thienopyridine

The title molecule, C7H5NS, is planar to within 0.009 A. Bond lengths at the heteroatoms are S1-C2 1.7276 (14), S1-C7a 1.7308 (13), N6-C5 1.354 and N6-C7 1.332 (2) A; the C-S-C angle is 90.76 (6)°. A libration analysis indicated corrections of 0.003-0.004 A. Short intermolecular contacts [S1...N6 3.229 (1) A] link the molecules into chains parallel to the y axis.

Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine

The synthesis and the 125I-apamin binding studies of original C-5- and C-8-substituted 1-(3,4-dimethoxy-benzyl)-2,2-dimethyl-1,2,3,4- tetrahydroisoquinoliniums and 1-(3,4-dimethoxy-benzyl)-6,6-dimethyl-4,5,6,7- tetrahydrothieno[2,3-c]pyridiniums were performed in order to find a reversible and selective SK channel blocker structurally related to N-methyl-laudanosine and N-methyl-noscapine. A bulky alkyl substituent in the C-8 position of the tetrahydroisoquinoline produces a clear increase in the affinity for the apamin sensitive binding sites. The presence of an electron-withdrawing group in the C-5 and C-8 positions is not a suitable substitution for the affinity of drugs structurally related to N-methyl-laudanosine. Thiophenic analogues and 8-methoxy derivatives possess a poor affinity for the apamin sensitive binding sites. Electrophysiological studies performed with the most effective compound showed a blockade of the apamin sensitive afterhyperpolarization in rat dopaminergic neurons.

FUNGAL CELL WALL SYNTHESIS GENE

A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed.Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.