2,5-DIMETHOXYBENZHYDRAZIDE

Base Information

• Chemical Name: 2,5-DIMETHOXYBENZHYDRAZIDE
• CAS No.: 17894-25-6
• Molecular Formula: C9H12N2O3
• Molecular Weight: 196.206
• Hs Code.: 2928000090
• Mol file: 17894-25-6.mol

Synonyms:2,5-Dimethoxybenzohydrazide;Benzoic acid, 2,5-dimethoxy-, hydrazide;

Chemical Property of 2,5-DIMETHOXYBENZHYDRAZIDE

Chemical Property:

• Melting Point: 89-91°C
• Refractive Index: 1.544
• PSA: 73.58000
• Density: 1.189 g/cm³
• LogP: 1.39850

Purity/Quality:

98%min ^*data from raw suppliers

2,5-Dimethoxybenzhydrazide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-DIMETHOXYBENZHYDRAZIDE

There total 3 articles about 2,5-DIMETHOXYBENZHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2,5-dimethoxybenzoate (2150-40-5) → 2,5-dimethoxybenzohydrazide (17894-25-6)

Guidance literature:

With hydrazine; In ethanol; for 12h; Heating;

DOI:10.1016/j.bmcl.2008.01.028

Reference yield:

2,5-dimethoxybenzoic acid (2785-98-0) → 2,5-dimethoxybenzohydrazide (17894-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: acetic acid; hydrazine hydrate / methanol / 3 h / Reflux

With sulfuric acid; hydrazine hydrate; acetic acid; In methanol;

DOI:10.1016/j.bioorg.2015.03.005

Reference yield:

→ 2,5-dimethoxybenzohydrazide (17894-25-6)

Guidance literature:

aus entspr. Ester;

upstream raw materials:

methyl 2,5-dimethoxybenzoate

2,5-dimethoxybenzoic acid

Downstream raw materials:

C₁₀H₁₁N₂O₃S₂^(1-)*K⁽¹⁺⁾

C₁₆H₁₄N₂O₄S

N-(2,5-bis-methoxybenzamido)-N'-phenylthiourea

Refernces

• 1、 Jiang, Qian-Qian,Darhkijav, Burenkhangai,Liu, Hao,Wang, Fang,Li, Zhao,Jiang, Yun-Bao. "Anion binding of N-(o-Methoxybenzamido)thioureas: Contribution of the intramolecular hydrogen bond in the N-benzamide moiety". experimental part. p. 543 - 549. Retrieved 2010/08/20.
• 2、 Skoumbourdis, Amanda P.,LeClair, Christopher A.,Stefan, Eduard,Turjanski, Adrian G.,Maguire, William,Titus, Steven A.,Huang, Ruili,Auld, Douglas S.,Inglese, James,Austin, Christopher P.,Michnick, Stephen W.,Xia, Menghang,Thomas, Craig J.. "Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors". supporting information; experimental part. p. 3686 - 3692. Retrieved 2010/03/24.