6-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-2-phenyl-, monosodium salt

Base Information

• Chemical Name: 6-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-2-phenyl-, monosodium salt
• CAS No.: 90033-89-9
• Molecular Formula: C16H11NO3.Na
• Molecular Weight: 287.25
• Mol file: 90033-89-9.mol

Synonyms:

Chemical Property of 6-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-2-phenyl-, monosodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-2-phenyl-, monosodium salt

There total 5 articles about 6-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-2-phenyl-, monosodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylic acid (90033-85-5) → sodium 4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylate (90033-89-9)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃; for 0.166667h; Sealed tube;

Reference yield:

ethyl 4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylate (308087-90-3,90033-86-6) → sodium 4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylate (90033-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / 4 h / 40 °C / Sealed tube

2: sodium hydroxide / ethanol; water / 0.17 h / 20 °C / Sealed tube

With water; sodium hydroxide; In ethanol; water;

Reference yield:

p-aminoethylbenzoate (94-09-7) → sodium 4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylate (90033-89-9)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid; sodium sulfate / chloroform / 48 h / Reflux

2: diphenylether / 0.17 h / 250 °C

3: sodium hydroxide; water / 4 h / 40 °C / Sealed tube

4: sodium hydroxide / ethanol; water / 0.17 h / 20 °C / Sealed tube

With water; toluene-4-sulfonic acid; sodium sulfate; sodium hydroxide; In diphenylether; ethanol; chloroform; water;

upstream raw materials:

4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylic acid

ethyl 4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylate

p-aminoethylbenzoate

ethyl 3-oxo-3-phenylpropionate

Refernces

• 1、 -. "4(1H)-QUINOLONE DERIVATIVES AND USES THEREOF". Paragraph 0296-0297. . Retrieved 2020/11/30.