2,5-Bis(trifluoromethyl)aniline

Base Information Edit

Chemical Name:2,5-Bis(trifluoromethyl)aniline
CAS No.:328-93-8
Molecular Formula:C8H5F6N
Molecular Weight:229.125
Hs Code.:29214990
European Community (EC) Number:629-040-2
DSSTox Substance ID:DTXSID00352132
Nikkaji Number:J1.908.597J
Wikidata:Q72447133
Mol file:328-93-8.mol

Synonyms:2,5-Bis(trifluoromethyl)aniline;328-93-8;2,5-di(trifluoromethyl)aniline;2,5-bis-(Trifluoromethyl)aniline;Benzenamine, 2,5-bis(trifluoromethyl)-;2,5-bis-trifluoromethylaniline;2,5-Bis(trifluoromethyl)-aniline;2,5-BIS(TRIFLUOROMETHYL)BENZENAMINE;MFCD00074940;alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-2,5-xylidine;Enamine_005232;2,5-ditrifluoromethylaniline;2,5-bis-trifluoromethylanilin;SCHEMBL330502;2,5-bis-trifluoromethyl-aniline;DTXSID00352132;HMS1408N18;BCP08855;2,5-Bis (trifluoro methyl) aniline;AKOS000115443;AC-3652;CS-W007922;PS-7734;2,5-Bis(trifluoromethyl)aniline, 99%;IDI1_007819;AM20060382;B2544;FT-0610260;EN300-02439;A821499;J-507275;Z56896763;alpha,alpha,alpha,alphaatrade mark,alphaatrade mark,alphaatrade mark-hexafluoro-2,5-Xylidine;2,5-Bis(trifluoromethyl)benzenamine;2,5-Di(trifluoromethyl)aniline;alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-2,5-Xylidine

Suppliers and Price of 2,5-Bis(trifluoromethyl)aniline

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,5-Bis(trifluoromethyl)aniline
10g
$ 185.00

TRC
2,5-Bis(trifluoromethyl)aniline
50g
$ 360.00

TRC
2,5-Bis(trifluoromethyl)aniline
5g
$ 95.00

TCI Chemical
2,5-Bis(trifluoromethyl)aniline >98.0%(GC)
5g
$ 58.00

TCI Chemical
2,5-Bis(trifluoromethyl)aniline >98.0%(GC)
25g
$ 211.00

SynQuest Laboratories
2,5-Bis(trifluoromethyl)aniline 98%
500 g
$ 255.00

SynQuest Laboratories
2,5-Bis(trifluoromethyl)aniline 98%
25 g
$ 15.00

SynQuest Laboratories
2,5-Bis(trifluoromethyl)aniline 98%
10 g
$ 10.00

SynQuest Laboratories
2,5-Bis(trifluoromethyl)aniline 98%
100 g
$ 65.00

Sigma-Aldrich
2,5-Bis(trifluoromethyl)aniline 99%
5g
$ 75.00

Total 137 raw suppliers

Chemical Property of 2,5-Bis(trifluoromethyl)aniline Edit

Chemical Property:

Appearance/Colour:Colorless or pale yellow liquid
Vapor Pressure:0mmHg at 25°C
Refractive Index:n20/D 1.432(lit.)
Boiling Point:177.9 °C at 760 mmHg
PKA:0.24±0.10(Predicted)
Flash Point:83.3 °C
PSA：26.02000
Density:1.443 g/cm³
LogP:3.88760
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly)
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:0
Exact Mass:229.03261814
Heavy Atom Count:15
Complexity:220

Purity/Quality:

99% ^*data from raw suppliers

2,5-Bis(trifluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn， T， Xi
Hazard Codes:Xn,T,Xi
Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39-45-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC(=C(C=C1C(F)(F)F)N)C(F)(F)F
Uses 2,5-Bis(trifluoromethyl)aniline is a haloalkul substituted aniline used in the preparation of anti-benign prostatic hyperplasia drug, Dutasteride (D735000). 2,5-Bis(trifluoromethyl)aniline may be used in chemical synthesis.

Technology Process of 2,5-Bis(trifluoromethyl)aniline

There total 7 articles about 2,5-Bis(trifluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 320-88-7
1,4-Bis(trifluoromethyl)-2-nitro-benzene

: 328-93-8
2,5-bis(trifluoromethyl)aniline

Guidance literature:: With hydrogen; nickel; In isopropyl alcohol; at 70 - 90 ℃; for 8h; under 3677.86 Torr;

Reference yield:

: 433-19-2
1,4-bis(trifluoromethyl)benzene

: 328-93-8
2,5-bis(trifluoromethyl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: disulfuric acid; sulfuric acid; nitric acid

2: SnCl₂+2H₂O; concentrated HCl

With hydrogenchloride; sulfuric acid; nitric acid; disulfuric acid; tin(ll) chloride;
DOI:10.1021/ja01116a025