Technology Process of Acetamide,
N-3-pyridinyl-N-[3-[1-[tris(1-methylethyl)silyl]-1H-indol-4-yl]phenyl]-
There total 6 articles about Acetamide,
N-3-pyridinyl-N-[3-[1-[tris(1-methylethyl)silyl]-1H-indol-4-yl]phenyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phosphate;
2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex;
In
1,4-dioxane;
at 100 ℃;
for 3h;
microwave;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: copper(l) iodide; caesium carbonate / 1,4-dioxane; N,N`-dimethylethylenediamine / 16 h / 110 °C
2: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 100 °C / Inert atmosphere; Reflux
With
potassium phosphate; copper(l) iodide; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; caesium carbonate;
In
1,4-dioxane; water; N,N`-dimethylethylenediamine;
2: Suzuki coupling;
DOI:10.1021/jm100659v
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 4 h / 90 °C
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 5 °C
2.2: 0 - 20 °C
3.1: potassium phosphate / chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II) / 1,4-dioxane / 3 h / 100 °C / Microwave irradiation
With
potassium phosphate; potassium acetate; sodium hydride;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II);
In
tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;
3.1: Suzuki Coupling;
