2,5-Dioxopyrrolidin-1-yl 6-hydrazinylnicotinate hydrochloride

Base Information

• Chemical Name: 2,5-Dioxopyrrolidin-1-yl 6-hydrazinylnicotinate hydrochloride
• CAS No.: 133081-27-3
• Molecular Formula: C10H10N4O4.ClH
• Molecular Weight: 286.675
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40927924
• Mol file: 133081-27-3.mol

Synonyms:SHNH;succinimidyl 6-hydrazinonicotinate

Chemical Property of 2,5-Dioxopyrrolidin-1-yl 6-hydrazinylnicotinate hydrochloride

Chemical Property:

• Vapor Pressure: 8.49E-10mmHg at 25°C
• Boiling Point: 491.3 °C at 760 mmHg
• Flash Point: 250.9 °C
• PSA: 114.62000
• LogP: 1.10120
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 286.0468825
• Heavy Atom Count: 19
• Complexity: 357

Purity/Quality:

98%Min ^*data from raw suppliers

HYDRALINK SHNH REAGENT 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)N(C1=O)OC(=O)C2=CN=C(C=C2)NN.Cl

Technology Process of 2,5-Dioxopyrrolidin-1-yl 6-hydrazinylnicotinate hydrochloride

There total 4 articles about 2,5-Dioxopyrrolidin-1-yl 6-hydrazinylnicotinate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Chloro-3-pyridinecarboxylic acid (5326-23-8) → succinimidyl 6-hydrazinopyridine-3-carboxylate hydrochloride (133081-27-3)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine hydrate / 4 h / 100 °C

2: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

3: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 °C

4: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1002/jlcr.3522

Reference yield:

6-hydrazinylnicotinic acid (133081-24-0) → succinimidyl 6-hydrazinopyridine-3-carboxylate hydrochloride (133081-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 °C

3: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1002/jlcr.3522

Reference yield:

6-({[(tert-butoxy)carbonyl]amino}amino)pyridine-3-carboxylic acid (133081-25-1) → succinimidyl 6-hydrazinopyridine-3-carboxylate hydrochloride (133081-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1002/jlcr.3522

upstream raw materials:

6-Chloro-3-pyridinecarboxylic acid

6-hydrazinylnicotinic acid

6-({[(tert-butoxy)carbonyl]amino}amino)pyridine-3-carboxylic acid

2-(N'-tert-butoxycarbonylhydrazino)pyridine-5-carboxylic acid 2,5-dioxopyrrolidin-1-yl ester

Downstream raw materials:

C₄₂H₄₆N₁₀O₂

Refernces