3-PYRIDIN-4-YL-PROPIONIC ACID

Base Information

• Chemical Name: 3-PYRIDIN-4-YL-PROPIONIC ACID
• CAS No.: 6318-43-0
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.165
• Hs Code.: 29333990
• Mol file: 6318-43-0.mol

Synonyms:4-Pyridinepropionicacid (6CI,7CI,8CI);3-(4-Pyridinyl)propanoic acid;3-(4-Pyridyl)propionic acid;NSC 31601;Pyrid-4-ylpropionic acid;b-(4-Pyridyl)propionic acid;

Chemical Property of 3-PYRIDIN-4-YL-PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 0.000234mmHg at 25°C
• Melting Point: 231℃
• Refractive Index: 1.546
• Boiling Point: 311.9 °C at 760 mmHg
• PKA: 4.20±0.10(Predicted)
• Flash Point: 142.4 °C
• PSA: 50.19000
• Density: 1.193 g/cm³
• LogP: 1.09880
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

3-(Pyridin-4-yl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-PYRIDIN-4-YL-PROPIONIC ACID

There total 16 articles about 3-PYRIDIN-4-YL-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(pyridin-4-yl)acrylic acid (84228-93-3) → 3-pyridin-4-yl-propionic acid (6318-43-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane; at 23 ℃; for 24h; under 760.051 Torr;

Reference yield: 92.0%

2-(pyridin-4-ylmethyl)malonic acid → 3-pyridin-4-yl-propionic acid (6318-43-0)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃; for 16h;

Reference yield: 84.0%

2-vinyl-1,3-dioxolane (3984-22-3) + 4-bromopyridin (1120-87-2) → 3-pyridin-4-yl-propionic acid (6318-43-0)

Guidance literature:

2-vinyl-1,3-dioxolane; 4-bromopyridin; With potassium carbonate; Pd-Tedicyp catalyst; In N,N-dimethyl-formamide; at 110 ℃; for 20h;

With sodium hydroxide; water; In N,N-dimethyl-formamide; at 50 - 80 ℃;

DOI:10.1016/j.tet.2004.09.061

upstream raw materials:

3-(pyridin-4-yl)propanenitrile

4-(3-Hydroxypropyl)pyridine

3-(pyridin-4-yl)acrylic acid

4-pyridinepropanoic acid methyl ester

Downstream raw materials:

ethyl 4-pyridinepropanoate

4-pyridinepropanoic acid methyl ester

4-(3-Hydroxypropyl)pyridine

Refernces

• 1、 Rafi, Shaik,Kandagatla, Bhaskar,Darapaneni, Balachennaiah,Oruganti, Srinivas. "Short & expedient synthesis of pyridine containing dihydrochalcone 1-(2-hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one: A non-nutritive artificial sweetener". . p. 459 - 464. Retrieved 2019/01/21.
• 2、 -. "CHEMOKINE RECEPTOR BINDING COMPOUNDS". Page/Page column 103-104. . Retrieved 2008/06/13.