4-Hydroxyphenyl 4-Methoxyphenyl ketone

Base Information

• Chemical Name: 4-Hydroxyphenyl 4-Methoxyphenyl ketone
• CAS No.: 61002-54-8
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• Mol file: 61002-54-8.mol

Synonyms:4-methoxy-4'-hydroxybenzophenone;4-Hydroxy-4'-methoxy-benzophenon;4-[(4-methoxyphenyl)carbonyl]phenol;4-hydroxy-4'-methoxybenzophenone;4-hydroxyphenyl 4-methoxyphenyl methanone;

Chemical Property of 4-Hydroxyphenyl 4-Methoxyphenyl ketone

Chemical Property:

• Vapor Pressure: 1.95E-07mmHg at 25°C
• Boiling Point: 413.8°Cat760mmHg
• Flash Point: 160.1°C
• PSA: 46.53000
• Density: 1.201g/cm³
• LogP: 2.63180
• Solubility.: Chloroform

Purity/Quality:

99% ^*data from raw suppliers

4-Hydroxy-4''-methoxybenzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Hydroxy-4''-methoxybenzophenone is an intermediate in the synthesis of Nitromifene Citrate (E/Z mixture) (N496700). Nitromifene Citrate s a non-steroidal estrogen antagonist. It is structurally similar to Tamoxifen (T006000) which is a selective estrogen response modifier (SERM).

Technology Process of 4-Hydroxyphenyl 4-Methoxyphenyl ketone

There total 26 articles about 4-Hydroxyphenyl 4-Methoxyphenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

chloroform (67-66-3,8013-54-5) + p-Iodophenol (540-38-5) + 4-methoxyphenylboronic acid (5720-07-0) → 4-hydroxy-4'-methoxybenzophenone (61002-54-8)

Guidance literature:

With C₃₃H₂₇N₂O₃PPd; potassium hydroxide; In toluene; at 80 ℃; Sealed tube;

DOI:10.1002/aoc.5414

Reference yield: 82.0%

4-methoxyphenylboronic acid (5720-07-0) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-hydroxy-4'-methoxybenzophenone (61002-54-8)

Guidance literature:

With tri-tert-butyl phosphine; potassium carbonate; acetone; bis(ethylene)rhodium(I) chloride dimer; In 1,4-dioxane; toluene; at 20 - 80 ℃;

DOI:10.1002/adsc.200600530

Reference yield: 74.0%

phenyl 4-methoxybenzoate (4181-97-9) → 4-hydroxy-4'-methoxybenzophenone (61002-54-8) + (2-hydroxyphenyl)(4-methoxyphenyl)methanone (18733-07-8)

Guidance literature:

With methanesulfonic acid; Methanesulfonic anhydride; at 65 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1055/s-0032-1316568

upstream raw materials:

4-methoxy-4'-nitrobenzophenone

phenyl 4-methoxybenzoate

methoxybenzene

4-hydroxy-benzoic acid

Downstream raw materials:

11-[4-(4-Methoxy-benzoyl)-phenoxy]-undecanoic acid methyl ester

4-(methoxymethoxy)-4'-methoxybenzophenone

(4-Carboxymethoxyphenyl)-4-methoxyphenylcarbinol

1-(4-ethoxy-phenyl)-2-bromo-1-(4-methoxy-phenyl)-ethane

Refernces

• 1、 Miyanishi, Shoji,Yamaguchi, Takeo. "Analysis of the degradation mechanism of the polyarylene ether anion-exchange membrane for alkaline fuel cell and water-splitting cell applications". . p. 8036 - 8044. Retrieved 2017/08/14.
• 2、 Jeon, Ingyu,Mangion, Ian K.. "An improved synthesis of hydroxy aryl ketones by fries rearrangement with methanesulfonic acid/methanesulfonic anhydride". experimental part. p. 1927 - 1930. Retrieved 2012/10/08.