4-Methoxybenzamide

Base Information

• Chemical Name: 4-Methoxybenzamide
• CAS No.: 3424-93-9
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.165
• Hs Code.: 29242990
• European Community (EC) Number: 222-319-6
• NSC Number: 11139
• UNII: Z85FX3977E
• DSSTox Substance ID: DTXSID40879434
• Nikkaji Number: J149.908D
• Wikidata: Q20059730
• ChEMBL ID: CHEMBL449635
• Mol file: 3424-93-9.mol

Synonyms:4-Methoxybenzamide;3424-93-9;p-Methoxybenzamide;p-Anisamide;Benzamide, 4-methoxy-;4-Methoxy benzamide;EINECS 222-319-6;4-methoxy-benzamide;BRN 1862847;UNII-Z85FX3977E;CHEMBL449635;Z85FX3977E;MFCD00007995;NSC-11139;4-10-00-00433 (Beilstein Handbook Reference);P-methyoxybenzamide;4-Methoxybenzamide, 98%;Oprea1_456315;SCHEMBL201761;SCHEMBL12015238;AMY3949;DTXSID40879434;CHEBI:194912;NSC11139;BDBM50340090;NSC 11139;STL482885;AKOS000266484;AB00908;CS-W022205;GS-6794;AC-17055;LS-27089;SY040631;FT-0600843;M1679;EN300-15615;F11797;W-106742;Q20059730;Z33546492;8424-93-9;8ZX

Chemical Property of 4-Methoxybenzamide

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 164-167 °C(lit.)
• Refractive Index: 1.546
• Boiling Point: 295.803 °C at 760 mmHg
• PKA: 16.34±0.50(Predicted)
• Flash Point: 161.563 °C
• PSA: 52.32000
• Density: 1.144 g/cm³
• LogP: 1.49440
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 139

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)N

Technology Process of 4-Methoxybenzamide

There total 158 articles about 4-Methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxybenzonitrile (874-90-8) → 4-methoxyphenylacetamide (3424-93-9)

Guidance literature:

With C₁₈H₅₇O₃P₆Ru₂⁽¹⁺⁾*C₆H₅O^(1-)*C₆H₆O; water; In 1,4-dioxane; for 6h; Time; Sealed tube; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.poly.2016.04.006

Reference yield: 99.0%

4-methoxy-benzaldehyde (123-11-5) → 4-methoxyphenylacetamide (3424-93-9)

Guidance literature:

With hydroxylamine; C₃₃H₂₈F₃N₅O₃Ru⁽¹⁺⁾*Cl^(1-); In water; at 60 ℃; for 0.5h; Catalytic behavior; Sonication;

DOI:10.1246/BCSJ.20200071

Reference yield: 93.0%

2-(4-methoxybenzoylamino)-2-methylpropionic acid (38388-44-2) → 4-methoxyphenylacetamide (3424-93-9)

Guidance literature:

With copper dichloride; In dimethyl sulfoxide; at 120 ℃; for 11h;

DOI:10.3998/ark.5550190.p009.726

upstream raw materials:

4-Methoxybenzophenone

4-methoxy-benzoyl chloride

cyanic acid

methoxybenzene

Downstream raw materials:

N-(4-methoxy-benzoyl)-N'-(4-methoxy-phenyl)-urea

2-(4-chlorophenyl)-1-(4-methoxyphenyl)ethanone

4-Methoxypropiophenone

1-(4-ethoxyphenyl)methanamine

Refernces

• 1、 Collado, Alba,Patrick, Scott R.,Gasperini, Danila,Meiries, Sebastien,Nolan, Steven P.. "Influence of bulky yet flexible N-heterocyclic carbene ligands in gold catalysis". . p. 1809 - 1814. Retrieved 2015.
• 2、 Ben-David, Yehoshoa,Diskin-Posner, Yael,Kar, Sayan,Milstein, David,Zhou, Quan-Quan,Zou, You-Quan. "Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration, and α-Deuterated Amide Formation via Metal Ligand Cooperation". . p. 10239 - 10245. Retrieved 2021/08/24.
• 3、 Mohammadi, Robabeh,Gholipour, Behnam,Alamgholiloo, Hassan,Rostamnia, Sadegh,Mohtasham, Hamed,Zonouzi, Afsaneh,Ramakrishna, Seeram,Shokouhimehr, Mohammadreza. "Nano-construction of CuO nanorods decorated with g-C3N4 nanosheets (CuO/g-C3N4-NS) as a superb colloidal nanocatalyst for liquid phase C[sbnd]H conversion of aldehydes to amides". . . Retrieved 2021/04/27.