N-(4-Methoxybenzoyl)-2-methylalanine

Base Information

• Chemical Name: N-(4-Methoxybenzoyl)-2-methylalanine
• CAS No.: 38388-44-2
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.255
• Mol file: 38388-44-2.mol

Synonyms:2-(4-methoxybenzoylamino)-2-methylpropionic acid

Chemical Property of N-(4-Methoxybenzoyl)-2-methylalanine

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-Methoxybenzoyl)-2-methylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-Methoxybenzoyl)-2-methylalanine

There total 4 articles about N-(4-Methoxybenzoyl)-2-methylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-benzoyl chloride (100-07-2) + 2-Aminoisobutyric acid (62-57-7) → 2-(4-methoxybenzoylamino)-2-methylpropionic acid (38388-44-2)

Guidance literature:

With sodium hydroxide; In water; at 0 - 20 ℃; for 5h;

DOI:10.1021/acs.joc.6b02257

Reference yield:

2-(p-Methoxybenzoylamino)-2-methylpropanol (38388-43-1) → 2-(4-methoxybenzoylamino)-2-methylpropionic acid (38388-44-2)

Guidance literature:

With silver(l) oxide;

Reference yield:

5-ethoxy-2-(4-methoxy-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole (38388-66-8) → 2-(4-methoxybenzoylamino)-2-methylpropionic acid (38388-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) HCl, Et₂O, (ii) H₂O

2: Ag₂O

With silver(l) oxide;

upstream raw materials:

2-(p-Methoxybenzoylamino)-2-methylpropanol

5-ethoxy-2-(4-methoxy-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

4-methoxybenzoyl azide

4-methoxy-benzoyl chloride

Downstream raw materials:

4-methoxyphenylacetamide

Refernces

• 1、 Li, Shuangjie,Zhu, Wei,Gao, Feng,Li, Chunpu,Wang, Jiang,Liu, Hong. "Palladium-Catalyzed Ortho-Alkoxylation of N-Benzoyl α-Amino Acid Derivatives at Room Temperature". . p. 126 - 134. Retrieved 2017/04/26.