2-Methoxy-3,5-dimethylpyrazine

Base Information

• Chemical Name: 2-Methoxy-3,5-dimethylpyrazine
• CAS No.: 92508-08-2
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.169
• Hs Code.: 2933990090
• European Community (EC) Number: 809-795-6
• DSSTox Substance ID: DTXSID30423905
• Nikkaji Number: J1.332.169H
• Wikidata: Q77371669
• Metabolomics Workbench ID: 49196
• Mol file: 92508-08-2.mol

Synonyms:2-methoxy-3,5-dimethylpyrazine

Chemical Property of 2-Methoxy-3,5-dimethylpyrazine

Chemical Property:

• PSA: 35.01000
• LogP: 1.10200
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 138.079312947
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxy-3,5-dimethylpyrazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CN=C(C(=N1)C)OC
• Uses: 2-Methoxy-3,5-dimethylpyrazine is a contaminant of cork with strong unpleasant smell found in wines with cork stoppers.

Technology Process of 2-Methoxy-3,5-dimethylpyrazine

There total 6 articles about 2-Methoxy-3,5-dimethylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

methanol (67-56-1) + 2-chloro-3,5-dimethylpyrazine (38557-72-1) → 2-methoxy-3,5-dimethylpyrazine (92508-08-2)

Guidance literature:

With sodium methylate; at 120 ℃; for 3h;

DOI:10.1002/ejoc.200500280

Reference yield: 40.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 3-hydroxy-2,6-dimethylpyrazine (60187-00-0) → 2-methoxy-3,5-dimethylpyrazine (92508-08-2) + 1,3,5-trimethyl-2(1H)-pyrazinone

Guidance literature:

In methanol; diethyl ether; at 20 ℃; for 16h;

DOI:10.1021/jf049484z

Reference yield:

methanol (67-56-1) + 2,6-dimethylpyrazine (108-50-9) → 2-methoxy-3,5-dimethylpyrazine (92508-08-2)

Guidance literature:

2,6-dimethylpyrazine; With chlorine; In tetrachloromethane; for 1h; Heating;

methanol; With sodium methylate; for 2h; Heating;

DOI:10.1021/jf990609n

upstream raw materials:

methanol

2,6-dimethylpyrazine

diazomethane

3-hydroxy-2,6-dimethylpyrazine

Refernces

• 1、 Simpson, Robert F.,Capone, Dimitra L.,Sefton, Mark A.. "Isolation and identification of 2-methoxy-3,5-dimethylpyrazine, a potent musty compound from wine corks". . p. 5425 - 5430. Retrieved 2007/10/03.