3,5-Dimethylpyrazin-2-ol

Base Information

• Chemical Name: 3,5-Dimethylpyrazin-2-ol
• CAS No.: 60187-00-0
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.14
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30519771
• Nikkaji Number: J1.054.158A
• Wikidata: Q82383207
• Mol file: 60187-00-0.mol

Synonyms:3,5-dimethylpyrazin-2-ol

Chemical Property of 3,5-Dimethylpyrazin-2-ol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 372.147°C at 760 mmHg
• Flash Point: 178.868°C
• PSA: 45.75000
• Density: 1.162g/cm³
• LogP: 0.38670
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 203

Purity/Quality:

98%Min ^*data from raw suppliers

3,5-Dimethylpyrazinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CNC(=O)C(=N1)C
• Uses: 3,5-Dimethylpyrazinol, has been shown to be a possible nucleobase residue of a primitive replicating molecule that preceded RNA.

Technology Process of 3,5-Dimethylpyrazin-2-ol

There total 10 articles about 3,5-Dimethylpyrazin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-acetoxy-2,6-dimethylpyrazine (86725-84-0) → 3-hydroxy-2,6-dimethylpyrazine (60187-00-0)

Guidance literature:

With potassium carbonate; for 0.5h; Ambient temperature;

Reference yield: 14.0%

2-chloro-3,5-dimethylpyrazine (38557-72-1) → 3-hydroxy-2,6-dimethylpyrazine (60187-00-0)

Guidance literature:

With hydrogenchloride; for 4h; Heating;

Reference yield:

2-oxopropanal (78-98-8) + alanine amide (4726-84-5) → 3,5-Dimethyl-2(1H)-pyrazinon (60187-00-0)

Guidance literature:

With sodium hydroxide; at -30 - -10 ℃;

DOI:10.1021/ja01126a070 DOI:10.1021/ja01169a023

upstream raw materials:

2-amino-3,5-dimethyl pyrazine

1-hydroxy-3,5-dimethyl-1H-pyrazin-2-one

2-oxopropanal

alanine amide

Downstream raw materials:

2-iodo-3,5-dimethyl-pyrazine

2-bromo-3,5-dimethyl-pyrazine

2-methoxy-3,5-dimethylpyrazine

Refernces

• 1、 -. "PYRAZINES, PYRIMIDINES AND PYRIDAZINES USEFUL IN THE TREATMENT OF SENILE DEMENTIA". . . Retrieved 2008/06/13.