3-(Boc-amino)-2-piperidone

Base Information

• Chemical Name: 3-(Boc-amino)-2-piperidone
• CAS No.: 99780-98-0
• Molecular Formula: C10H18N2O3
• Molecular Weight: 214.265
• Mol file: 99780-98-0.mol

Synonyms:tert-butyl N-(2-oxopiperidin-3-yl)carbamate;

Chemical Property of 3-(Boc-amino)-2-piperidone

Chemical Property:

• Vapor Pressure: 8.68E-07mmHg at 25°C
• Boiling Point: 405.6±34.0 °C(Predicted)
• PKA: 11.05±0.20(Predicted)
• PSA: 74.41000
• Density: 1.11±0.1 g/cm3(Predicted)
• LogP: 1.27000
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

3-(Boc-amino)-2-piperidone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Boc-amino)-2-piperidone

There total 6 articles about 3-(Boc-amino)-2-piperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-aminopiperidin-2-one (1892-22-4,4077-38-7,34294-79-6,88763-76-2) + di-tert-butyl dicarbonate (24424-99-5) → (+/-)-3-<(tert-butoxycarbonyl)amino>-2-piperidone (99780-98-0)

Guidance literature:

With triethylamine; In methanol; at 0 - 20 ℃;

Reference yield: 84.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-aminopiperidin-2-one hydrochloride (138377-80-7,406216-02-2) → (+/-)-3-<(tert-butoxycarbonyl)amino>-2-piperidone (99780-98-0)

Guidance literature:

3-aminopiperidin-2-one hydrochloride; With triethylamine; at 20 ℃; for 0.166667h;

di-tert-butyl dicarbonate; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b03786

Reference yield: 66.0%

Nα-(t-butoxycarbonyl)ornithine (21887-64-9) → (+/-)-3-<(tert-butoxycarbonyl)amino>-2-piperidone (99780-98-0)

Guidance literature:

With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; for 2h;

upstream raw materials:

3-aminopiperidin-2-one

di-tert-butyl dicarbonate

2,5-diaminopentanoic acid

N^α-(t-butoxycarbonyl)ornithine

Downstream raw materials:

(+/-)-1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-piperidone

C₂₄H₂₆F₆N₄O₂S

3-amino-1-methylpiperidin-2-one hydrochloride

Refernces

• 1、 -. "ACC INHIBITORS AND USES THEREOF". Paragraph 0410. . Retrieved 2017/05/17.
• 2、 -. "NITROGEN-CONTAINING HETEROCYCLIC COMPOUND". Paragraph 0789. . Retrieved 2013/03/26.