3-Aminopiperidin-2-one

Base Information

• Chemical Name: 3-Aminopiperidin-2-one
• CAS No.: 1892-22-4
• Molecular Formula: C₅H₁₀N₂O
• Molecular Weight: 114.147
• Hs Code.: 29333990
• European Community (EC) Number: 805-737-9
• DSSTox Substance ID: DTXSID30409421,DTXSID90862775
• Metabolomics Workbench ID: 37204
• Nikkaji Number: J782.585D
• Wikidata: Q27145898
• Mol file: 1892-22-4.mol

Synonyms:3-amino-2-piperidone;3-aminopiperidine-2-one

Chemical Property of 3-Aminopiperidin-2-one

Chemical Property:

• Vapor Pressure: 0.000723mmHg at 25°C
• Refractive Index: 1.476
• Boiling Point: 307.5 °C at 760 mmHg
• PKA: 16.00±0.40(Predicted)
• Flash Point: 139.8 °C
• PSA: 55.12000
• Density: 1.071 g/cm³
• LogP: 0.25280
• Storage Temp.: -20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 114.079312947
• Heavy Atom Count: 8
• Complexity: 103

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Aminopiperidin-2-one(>90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(C(=O)NC1)N
• Uses: 3-Aminopiperidin-2-one (>90%) can be used as a biomarker to diagnose the silent phase of Alzeihmer’s disease.

Technology Process of 3-Aminopiperidin-2-one

There total 11 articles about 3-Aminopiperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

L-ornithine hydrochloride (3184-13-2,36630-89-4) → 3-aminopiperidin-2-one (1892-22-4,4077-38-7,34294-79-6,88763-76-2)

Guidance literature:

With aluminum oxide; sodium hydroxide; In toluene; for 1.5h; Heating;

DOI:10.1016/S0040-4020(02)00278-8

Reference yield: 79.0%

L-ornithine hydochloride (1069-31-4,3184-13-2,6211-16-1,15160-12-0,16682-12-5,20724-48-5,22834-83-9,26982-21-8,66837-02-3,99815-05-1,36630-89-4) → 3-aminopiperidin-2-one (1892-22-4,4077-38-7,34294-79-6,88763-76-2)

Guidance literature:

With aluminum oxide; In toluene; for 3h; Heating;

DOI:10.1016/S0040-4039(00)93171-X

Reference yield: 57.0%

D-ornithine hydrochloride (16682-12-5,36630-89-4) → 3-aminopiperidin-2-one (1892-22-4,4077-38-7,34294-79-6,88763-76-2)

Guidance literature:

With sodium hydroxide; In water; for 0.166667h;

DOI:10.1039/c8cc09541h

upstream raw materials:

ornithine methyl ester

L-ornithine hydochloride

(S)-(-)-3-aminopiperidin-2-one

L-ornithine hydrochloride

Downstream raw materials:

(S)-(-)-3-aminopiperidin-2-one

(R)-(+)-3-Amino-2-piperidinon

N-(2'-oxopiperidin-3'-yl)benzamide

Potassium; 2-(2-oxo-piperidin-3-ylcarbamoyl)-benzenesulfonate

Refernces

• 1、 Muthusamy, Sengodagounder,Gangadurai, Chinnakuzhanthai. "Domino Reactions of Bis-Diazo Compounds: Rhodium(II) Acetate Catalyzed Diastereoselective Synthesis of Epoxy- and Epithio-Bridged Heterocycle-Fused Quinolizinone Analogues". . p. 2213 - 2225. Retrieved 2016/07/15.
• 2、 -. "UREA DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL USE OF THESE". Page/Page column 92. . Retrieved 2010/11/29.