Benzeneethanamine, N-2-propenyl-, hydrochloride

Base Information

• Chemical Name: Benzeneethanamine, N-2-propenyl-, hydrochloride
• CAS No.: 99858-44-3
• Molecular Formula: C₁₁H₁₅N*ClH
• Molecular Weight: 197.708
• Mol file: 99858-44-3.mol

Synonyms:

Chemical Property of Benzeneethanamine, N-2-propenyl-, hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneethanamine, N-2-propenyl-, hydrochloride

There total 3 articles about Benzeneethanamine, N-2-propenyl-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

allyl-(4-methoxy-benzyl)-phenethyl-amine → N-phenethylprop-2-en-1-aminium hydrochloride (99858-44-3)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane;

DOI:10.1016/j.tetlet.2006.05.038

Reference yield:

N-(4-methoxybenzyl)-2-phenylethan-1-amine (3241-00-7) → N-phenethylprop-2-en-1-aminium hydrochloride (99858-44-3)

Guidance literature:

Multi-step reaction with 2 steps

1: DIAD; polymer-bound triphenylphosphine / tetrahydrofuran

2: HCl / CH₂Cl₂; diethyl ether

With hydrogenchloride; di-isopropyl azodicarboxylate; polymer-bound triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/j.tetlet.2006.05.038

Reference yield:

2-phenylethylamine hydrochloride (156-28-5) + 3-chloroprop-1-ene (107-05-1) → N-phenethylprop-2-en-1-aminium hydrochloride (99858-44-3)

Guidance literature:

2-phenylethylamine hydrochloride; With di-tert-butyl dicarbonate;

3-chloroprop-1-ene; With sodium hydride; In mineral oil;

With trifluoroacetic acid;

DOI:10.1021/jm5006918

upstream raw materials:

N-(4-methoxybenzyl)-2-phenylethan-1-amine

2-phenylethylamine hydrochloride

3-chloroprop-1-ene

Refernces

• 1、 J?st, Christian,Nitsche, Christoph,Scholz, Therese,Roux, Lionel,Klein, Christian D.. "Promiscuity and selectivity in covalent enzyme inhibition: A systematic study of electrophilic fragments". supporting information. p. 7590 - 7599. Retrieved 2014/12/11.