4-Amino-2-chloropyrimidine

Base Information

• Chemical Name: 4-Amino-2-chloropyrimidine
• CAS No.: 7461-50-9
• Molecular Formula: C4H4ClN3
• Molecular Weight: 129.549
• Hs Code.: 29335990
• Mol file: 7461-50-9.mol

Synonyms:Pyrimidine, 4-amino-2-chloro- (7CI,8CI);2-Chloro-4-aminopyrimidine;2-Chloro-4-pyrimidinamine;2-Chloropyrimidin-4-ylamine;NSC 403512;

Chemical Property of 4-Amino-2-chloropyrimidine

Chemical Property:

• Appearance/Colour: Colorless to slight yellow liquid
• Melting Point: 197-205 °C
• Boiling Point: 338.8 °C at 760 mmHg
• PKA: 2.30±0.10(Predicted)
• Flash Point: 158.7 °C
• PSA: 51.80000
• Density: 1.438 g/cm³
• LogP: 1.29340
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-2-chloropyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-Amino-2-chloropyrimidine

There total 3 articles about 4-Amino-2-chloropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chloro-4-pyrimidinecarboxamide (22536-66-9) → 2-chloropyrimidin-4-amine (7461-50-9)

Guidance literature:

With bromine; sodium hydroxide; In water; at 60 ℃; for 8h; Cooling with ice;

Reference yield: 69.0%

2,6-Dichloropyrimidine (3934-20-1) → 2-chloropyrimidin-4-amine (7461-50-9) + 2-amino-4-chloropyrimidine (3993-78-0)

Guidance literature:

With ammonium hydroxide; In water; at 20 ℃;

Reference yield:

2,6-Dichloropyrimidine (3934-20-1) + ammonia (7664-41-7) → 2-chloropyrimidin-4-amine (7461-50-9) + 2-amino-4-chloropyrimidine (3993-78-0)

Guidance literature:

at 100 ℃;

upstream raw materials:

2,6-Dichloropyrimidine

ammonia

2-chloro-4-pyrimidinecarboxamide

Downstream raw materials:

N²-phenyl-pyrimidine-2,4-diamine

pyrimidin-4-amine

Cytosine

5-(4-aminopyrimidin-2-ylamino)-2-methylphenol

Refernces

• 1、 -. "Novel nucleoside compounds and preparation method thereof". Paragraph 0062; 0063; 0064; 0065; 0066; 0067. . Retrieved 2017/04/26.
• 2、 Xu, Chunyan,Cheng, Chuanjie,Liu, Hongtao,Liu, Bo. "Highly efficient, chemoselective syntheses of 2-methoxy-4-substituted pyrimidines". scheme or table. p. 545 - 548. Retrieved 2012/06/01.