2-Amino-4-chloropyrimidine

Base Information

• Chemical Name: 2-Amino-4-chloropyrimidine
• CAS No.: 3993-78-0
• Molecular Formula: C4H4ClN3
• Molecular Weight: 129.549
• Hs Code.: 29335990
• Mol file: 3993-78-0.mol

Synonyms:Pyrimidine,2-amino-4-chloro- (6CI,7CI,8CI);(4-Chloropyrimidin-2-yl)amine;4-Chloro-2-pyrimidinamine;NSC 10872;NSC 25184;2-Amino-4-chloridepyrimidine;

Chemical Property of 2-Amino-4-chloropyrimidine

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 155-160 °C (dec.)
• Refractive Index: 1.618
• Boiling Point: 314.609 °C at 760 mmHg
• PKA: 3.55±0.10(Predicted)
• Flash Point: 144.07 °C
• PSA: 51.80000
• Density: 1.437g/cm³
• LogP: 1.29340
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: Soluble in dimethyl sulfoxide.

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4-chloropyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-36/39-60

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-4-chloropyrimidine is a substrate used in a palladium-catalyzed cyanation with zinc(II) cyanide. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields. Substrate used in a palladium-catalyzed cyanation with zinc(II) cyanide.

Technology Process of 2-Amino-4-chloropyrimidine

There total 11 articles about 2-Amino-4-chloropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-chloro-2-methanesulfonylpyrimidine (97229-11-3) → 2-amino-4-chloropyrimidine (3993-78-0)

Guidance literature:

With aq. NH₃; In isopropyl alcohol;

Reference yield: 95.0%

2-amino-4-hydroxypyrimidine (108-53-2,100643-25-2) → 2-amino-4-chloropyrimidine (3993-78-0)

Guidance literature:

With pyridine; trichlorophosphate; at 180 ℃; for 2h; under 150.015 - 900.09 Torr; Neat (no solvent);

DOI:10.1021/jo2003715

Reference yield: 92.0%

isocytosine (108-53-2,145358-63-0,674-97-5,176772-97-7) → 2-amino-4-chloropyrimidine (3993-78-0)

Guidance literature:

isocytosine; With chlorosulfonic acid; trichlorophosphate; at 20 - 95 ℃; Inert atmosphere;

With ammonium hydroxide; In water; at 20 ℃; pH=~ 7; Cooling wit ice;

upstream raw materials:

2,6-Dichloropyrimidine

ammonia

2-amino-4-hydroxypyrimidine

4-chloro-2-methanesulfonylpyrimidine

Downstream raw materials:

4-(4-chloro-pyrimidin-2-ylamino)-N-(2-pyrrolidin-1-yl-ethyl)-benzenesulfonamide

4-fluoro-pyrimidin-2-ylamine

4-methoxypyrimidin-2-amine

4-iodo-2-aminopyrimidine

Refernces

• 1、 -. "Novel nucleoside compounds and preparation method thereof". Paragraph 0062; 0063; 0064; 0065; 0066; 0067. . Retrieved 2017/04/26.
• 2、 Pan, Li,Jiang, Ying,Liu, Zhen,Liu, Xing-Hai,Liu, Zhuo,Wang, Gang,Li, Zheng-Ming,Wang, Di. "Synthesis and evaluation of novel monosubstituted sulfonylurea derivatives as antituberculosis agents". experimental part. p. 18 - 26. Retrieved 2012/07/01.