METHOXY-PHENYL-ACETIC ACID METHYL ESTER

Base Information

• Chemical Name: METHOXY-PHENYL-ACETIC ACID METHYL ESTER
• CAS No.: 3558-61-0
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Hs Code.: 2918990090
• Mol file: 3558-61-0.mol

Synonyms:Aceticacid, methoxyphenyl-, methyl ester (6CI,7CI,8CI);Methyl2-methoxy-2-phenylacetate;Methyl o-methylmandelate;Methyl a-methoxyphenylacetate;NSC401792;a-Methoxyphenylacetic acid methylester;Methoxy-phenyl-acetic acid methyl e; ster;Methyl methoxy(phenyl)acetate;

Chemical Property of METHOXY-PHENYL-ACETIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.498
• Boiling Point: 258 °C at 760 mmHg
• Flash Point: 88.3 °C
• PSA: 35.53000
• Density: 1.086 g/cm³
• LogP: 1.54710

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHOXY-PHENYL-ACETIC ACID METHYL ESTER

There total 82 articles about METHOXY-PHENYL-ACETIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + methanol (67-56-1) → methyl 2-methoxy-2-phenylacetate (3558-61-0)

Guidance literature:

With dihydrogen peroxide; methyltrioxorhenium(VII); at 25 ℃; for 3h;

DOI:10.1039/a704496h

Reference yield: 98.0%

methanol (67-56-1) + Methyl phenyldiazoacetate (22979-35-7) → methyl 2-methoxy-2-phenylacetate (3558-61-0)

Guidance literature:

With rhodium (II) octanoate dimer; In dichloromethane;

DOI:10.1002/chem.201101590

Reference yield: 98.0%

(S)-Mandelic acid (17199-29-0) + methyl iodide (74-88-4) → (S)-methyl 2-methoxy-2-phenylacetate (3558-61-0,32174-46-2,56143-21-6,26164-27-2)

Guidance literature:

With silver(l) oxide; for 1h; Heating;

DOI:10.1071/CH9902045

upstream raw materials:

methanol

rac-methoxyphenylacetic acid

dimethyl α-bromo-α-phenylmalonate

sodium methylate

Downstream raw materials:

(+/-)-2-methoxy-2-phenylacetamide

(S)-2-methoxy-2-phenylacetic acid

(β-oxy-α-methoxy-isobutyl)-benzene

3-(α-methoxy-benzyl)-pentan-3-ol

Refernces

• 1、 Kolos, Andrey V.,Nelyubina, Yulia V.,Perekalin, Dmitry S.,Sundararaju, Basker. "Synthesis of Overloaded Cyclopentadienyl Rhodium(III) Complexes via Cyclotetramerization of tert-Butylacetylene". supporting information. p. 3712 - 3719. Retrieved 2021/09/18.
• 2、 Ciszewski, Lukasz W.,Durka, Jakub,Gryko, Dorota. "Photocatalytic Alkylation of Pyrroles and Indoles with α-Diazo Esters". supporting information. p. 7028 - 7032. Retrieved 2019/09/12.