2-ACETAMIDO-6-METHYLPYRIDINE

Base Information

• Chemical Name: 2-ACETAMIDO-6-METHYLPYRIDINE
• CAS No.: 5327-33-3
• Molecular Formula: C8H10N2O
• Molecular Weight: 150.18
• Hs Code.: 2933399090
• Mol file: 5327-33-3.mol

Synonyms:Acetamide,N-(6-methyl-2-pyridyl)- (8CI);2-Acetamido-6-methylpyridine;2-Acetylamino-6-methylpyridine;6-Acetamido-2-picoline;N-(6-Methyl-2-pyridinyl)acetamide;N-[6-Methylpyridyl]acetamide;NSC 132115;NSC 3315;

Chemical Property of 2-ACETAMIDO-6-METHYLPYRIDINE

Chemical Property:

• Appearance/Colour: Off-white to white crystalline powder
• Vapor Pressure: 0.000295mmHg at 25°C
• Melting Point: 87.0 to 91.0 °C
• Refractive Index: 1.572
• Boiling Point: 321.6 °C at 760 mmHg
• PKA: 13.82±0.70(Predicted)
• Flash Point: 148.3 °C
• PSA: 41.99000
• Density: 1.137 g/cm³
• LogP: 1.42140
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

2-Acetamido-6-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-ACETAMIDO-6-METHYLPYRIDINE

There total 13 articles about 2-ACETAMIDO-6-METHYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Amino-6-methylpyridine (1824-81-3) + acetic anhydride (108-24-7) → 2-acetylamino-6-methylpyridine (5327-33-3)

Guidance literature:

at 60 - 70 ℃; for 1.5h;

DOI:10.1021/jo960433d

Reference yield: 93.0%

2-Amino-6-methylpyridine (1824-81-3) + acetyl chloride (75-36-5) → 2-acetylamino-6-methylpyridine (5327-33-3)

Guidance literature:

With triethylamine; In toluene; at 5 - 20 ℃; for 2h;

DOI:10.1016/j.poly.2014.04.016

Reference yield: 85.0%

2-Amino-6-methylpyridine (1824-81-3) + acetic acid (64-19-7,77671-22-8) → 2-acetylamino-6-methylpyridine (5327-33-3)

Guidance literature:

With ZIF-8; In 2,2,2-trifluoroethanol; at 40 ℃; for 1.5h;

DOI:10.1055/s-0037-1610159

upstream raw materials:

2-Amino-6-methylpyridine

acetic anhydride

acetic acid

5-Oximinohexanenitrile

Downstream raw materials:

2-Amino-6-methylpyridine

2-acetylamino-6-(4-nitrostyryl)pyridine

N-(5-bromo-6-methyl-pyridin-2-yl)-acetamide

N-(6-bromomethyl-2-pyridinyl)-2-acetamide

Refernces

• 1、 Smolentsev, Anton I.,Lider, Elisaveta V.,Lavrenova, Ludmila G.,Sheludyakova, Liliya A.,Bogomyakov, Artem S.,Vasilevsky, Sergei F.. "Steric influence of the 6-methyl group on the molecular and crystal structures of copper(II) chloride complexes with 2-(N-acetylamino)-6- methylpyridine". . p. 81 - 88. Retrieved 2014.
• 2、 Alamgholiloo, Hassan,Rostamnia, Sadegh,Hassankhani, Asadollah,Banaei, Reza. "Synthesis of a Zeolitic Imidazolate-Zinc Metal-Organic Framework and the Combination of its Catalytic Properties with 2,2,2-Trifluoroethanol for N-Formylation". supporting information. p. 1593 - 1596. Retrieved 2018/06/08.
• 3、 Basak, Debajyoti,Sridhar, Sucheta,Bera, Amal K.,Madhavan, Nandita. "Cation-halide transport through peptide pores containing aminopicolinic acid". supporting information. p. 4712 - 4717. Retrieved 2016/06/09.