4-(TRIMETHYLSILYL)ANISOLE

Base Information

• Chemical Name: 4-(TRIMETHYLSILYL)ANISOLE
• CAS No.: 877-68-9
• Molecular Formula: C10H16 O Si
• Molecular Weight: 180.322
• Hs Code.: 29310099
• Mol file: 877-68-9.mol

Synonyms:Silane,(4-methoxyphenyl)trimethyl- (9CI); Silane, (p-methoxyphenyl)trimethyl-(6CI,7CI,8CI); (4-Methoxyphenyl)trimethylsilane;(p-Methoxyphenyl)trimethylsilane; (p-Methoxyphenyl)trimethylsilicon;4-Anisyltrimethylsilane; 4-Trimethylsilylanisole; p-(Trimethylsilyl)anisole;p-Anisyltrimethylsilane

Chemical Property of 4-(TRIMETHYLSILYL)ANISOLE

Chemical Property:

• Boiling Point: 223 °C
• PSA: 9.23000
• Density: 0.928
• LogP: 2.24040

Purity/Quality:

98%Min ^*data from raw suppliers

4-(TRIMETHYLSILYL)ANISOLE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(TRIMETHYLSILYL)ANISOLE

There total 37 articles about 4-(TRIMETHYLSILYL)ANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chloro-trimethyl-silane (75-77-4) + 1-bromo-4-methoxy-benzene (104-92-7) → 4-trimethylsilylanisole (877-68-9)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jo900088x

Reference yield: 100.0%

1-bromo-4-methoxy-benzene (104-92-7) → 4-trimethylsilylanisole (877-68-9)

Guidance literature:

1-bromo-4-methoxy-benzene; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.25h;

With chloro-trimethyl-silane; at 20 ℃;

Reference yield: 99.0%

chloro-trimethyl-silane (75-77-4) + para-iodoanisole (696-62-8) → 4-trimethylsilylanisole (877-68-9)

Guidance literature:

para-iodoanisole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at 20 ℃; for 17h; Inert atmosphere;

DOI:10.1002/chem.201601163

upstream raw materials:

chloro-trimethyl-silane

p-methoxyphenyllithium

4-methoxyphenyl magnesium bromide

1-bromo-4-methoxy-benzene

Downstream raw materials:

1-fluoro-4-methoxybenzene

methoxybenzene

trimethylphenylsilane

4-methoxynitrosobenzene

Refernces

• 1、 Ozaki, Tomoya,Kaga, Atsushi,Saito, Hayate,Yorimitsu, Hideki. "Generation of Aryllithium Reagents from N -Arylpyrroles Using Lithium". . p. 3019 - 3028. Retrieved 2021/06/02.
• 2、 Hitoshio, Kenshiro,Yamagishi, Hiroki,Shimokawa, Jun,Yorimitsu, Hideki. "Sodium silylsilanolate enables nickel-catalysed silylation of aryl chlorides". supporting information. p. 6867 - 6870. Retrieved 2021/07/19.