Cyclopropanemethylamine

Base Information

• Chemical Name: Cyclopropanemethylamine
• CAS No.: 2516-47-4
• Molecular Formula: C4H9N
• Molecular Weight: 71.1222
• Hs Code.: 29213099
• European Community (EC) Number: 219-737-6
• DSSTox Substance ID: DTXSID4062482
• Nikkaji Number: J80.509B
• Wikidata: Q72439410
• Mol file: 2516-47-4.mol

Synonyms:Cyclopropylmethanamine;Cyclopropylmethylamine;2516-47-4;Cyclopropanemethylamine;Cyclopropanemethanamine;(Aminomethyl)cyclopropane;Aminomethylcyclopropane;1-cyclopropylmethanamine;MFCD00037147;EINECS 219-737-6;Cyclopropane methyl amine;cyclopropylmethylamin;cyclopropanmethylamine;cyclopropyhnethylamine;Cylopropanemethylamine;cyclopropyl methanamine;cyclopropylmethyl amine;cyclopropylmethyl-amine;N-Methylcyclopropanamne;aminomethyl-cyclopropane;cyclopropane methylamine;cyclopropane-methylamine;cyclopropyl methaneamine;Aminomethyl cyclopropane;C-cyclopropylmethylamine;(cyclopropyl)methylamine;(cyclopropylmethyl)amine;1-cyclopropylmethylamine;2-cyclopropylmethylamine;Cyclopropylmethanamine #;cyclopropane-methyl-amine;C-cyclopropyl-methylamine;(cyclopropylmethyl)-amine;2-cyclopropylmethyl amine;C-Cyclopropyl methylamine;(aminomehtyl) cyclopropane;1-cyclopropylmethane amine;C-cyclopropyl methyl amine;Cyclopropane-1-methanamine;Integrase inhibitor, R3{1};2516-47-4 (anhydrous);DTXSID4062482;BDBM93345;IGSKHXTUVXSOMB-UHFFFAOYSA-;BCP34300;CS-D1471;STR01428;BBL027928;STK328116;AKOS000200048;AM61420;SB75361;AC-13087;BP-11376;BB 0241821;C2345;FT-0602230;EN300-27211;F11902;Cyclopropanemethylamine, purum, >=96.0% (GC);A854260;J-015846;J-523674;W-107257;F2191-0267;Z237573792;9L6

Chemical Property of Cyclopropanemethylamine

Chemical Property:

• Appearance/Colour: clear colourless to slightly yellow liquid
• Vapor Pressure: 67.5mmHg at 25°C
• Refractive Index: n20/D 1.434(lit.)
• Boiling Point: 86.1 °C at 760 mmHg
• PKA: 10.41±0.29(Predicted)
• Flash Point: -23 °F
• PSA: 26.02000
• Density: 0.912 g/cm³
• LogP: 1.05540
• Storage Temp.: Flammables area
• Water Solubility.: Fully miscible in water.
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 71.073499291
• Heavy Atom Count: 5
• Complexity: 30.6

Purity/Quality:

99% ^*data from raw suppliers

Cyclopropylmethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F, C
• Hazard Codes: F,C
• Statements: 11-34
• Safety Statements: 16-26-36/37/39-45-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC1CN
• Uses: Aminomethylcyclopropane is a cyclic compound with structural analogy to glycine used in studies of potential inhibitors of glycine cleavage system of brain and liver mitochondria. Cyclopropanemethylamine used in studies of potential inhibitors of glycine cleavage system of brain and liver mitochondria. It is used in chemical synthesis.

Technology Process of Cyclopropanemethylamine

There total 7 articles about Cyclopropanemethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Cyprazepam (15687-07-7) → 6-Chlor-2-methyl-4-phenyl-3,4-dihydrochinazolin (17433-16-8) + cyclopropanemethylamine (2516-47-4)

Guidance literature:

In methanol; water; for 14h; Mechanism; cathodic reduction, -1.480 V, Hg cathode, acetate buffer;

DOI:10.1002/ardp.19923250810

Reference yield: 65.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 1-amino-2-propene (107-11-9,30551-89-4) → cyclopropanemethylamine (2516-47-4)

Guidance literature:

bis(benzonitrile)palladium(II) dichloride; In diethyl ether; dichloromethane; at 5 - 10 ℃; for 0.5h;

DOI:10.1055/s-1990-26844

Reference yield: 53.0%

cyclopropropanecarbonitrile (5500-21-0) → cyclopropanemethylamine (2516-47-4)

Guidance literature:

With sodium tetrahydroborate; nickel dichloride; In tetrahydrofuran; at 25 ℃; for 16h; Temperature; Inert atmosphere; Large scale;

upstream raw materials:

cyclopropropanecarbonitrile

diazomethane

1-amino-2-propene

Cyprazepam

Downstream raw materials:

Cyclopropanecarboxaldehyde

(isothiocyanatomethyl)cyclopropane

N-cyclopropylmethyl-2-(3-phenoxyphenyl)propionamide

(E)-3-(4-Butylamino-3,5-dichloro-phenyl)-N-cyclopropylmethyl-acrylamide

Refernces

• 1、 -. "Preparation method of cyclopropyl methylamine". Paragraph 0012; 0013; 0014; 0015. . Retrieved 2019/08/14.
• 2、 Roman, Daniela Sustac,Charette, Andre B.. "C-H functionalization of cyclopropanes: A practical approach employing a picolinamide auxiliary". supporting information. p. 4394 - 4397. Retrieved 2013/09/24.