5500-21-0Relevant articles and documents
Direct Evidence for the Hydroxide Extraction Mechanism in the Phase Transfer Catalyzed Cyclopropanation of 4-Halobutyronitrile in a Solid-Liquid System
Cohen, Shlomo,Zoran, Ami,Sasson, Yoel
, p. 9815 - 9818 (1998)
The Hoffman degradation reaction is proposed as an unequivocal proof for the validity of the extraction mechanism in Phase Transfer Catalysis (PTC) in the presence of solid NaOH. 4-Chlorobutyronitrile is found to yield cyclopropyl cyanide via an extraction route while 4-bromobutyronitrile reacts to form the same product by the prevalent interfacial mechanism.
Novel method and technology for synthesizing cyclopropyl ammonia
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Paragraph 0017, (2021/09/21)
The invention discloses a synthesis process route of a cyclopropane synthetic route. In the process route, cyanocyclopropane 1 - formic acid (-1 -) and (1) are subjected to hydrolysis under the action of a strong base to generate 1-cyanocyclopropane 1 - formic acid (-1 -), (2) decarboxylation to generate cyclopropanecarboxamide (2 3), and (4 4 3) subjected to Hoffman rearrangement to obtain the target product cyclopropysite. The process route is longer than the production process in the present stage, the reaction route is long, the use of high-temperature and high-pressure is avoided, the danger is reduced, and the safety is improved. The requirement of the reaction equipment is reduced, the used raw materials are easy to obtain, operation is easy, safety and environmental protection are achieved, and industrial production can be realized.
A cyclopropyl armor cyanogen method for preparing derivatives of
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Paragraph 0035; 0036, (2016/12/22)
The invention relates to a preparation method of a cyclopropyl methyl cyanide derivative with a general formula I. The preparation method is as below: first synthesizing cyclopropyl formonitrile by using cyclopropanecarboxamide as raw material, then synthesizing a halogenated butyronitrile derivative, and finally synthesizing the target product cyclopropyl methyl cyanide derivative. The invention provides a complete process route, and carefully investigates and researches raw materials and process conditions in each step, so that the method provided by the invention is more efficient and secure, and low in energy consumption and cost, and applicable to large-scale industrialized production.