78104-88-8Relevant articles and documents
A process for preparing 1-methyl propyl formic acid method
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Paragraph 0038; 0039, (2017/02/09)
The invention discloses a method for preparing 1-methyl cyclopropane carboxylic acid and belongs to the fields of fine chemical engineering and medical intermediates. The method comprises the following steps: by taking methacrylic acid (ester or salt), or methacrylonitrile or methacrylamide as a raw material, carrying out a cyclopropanation reaction with trihalide in the presence of an alkali to generate 2,2-geminal halide (III); carrying out a reaction between the 2,2-geminal halide (III) and metallic sodium to remove halogen atoms on the ring so as to generate methyl cyclopropionate or methyl cyclopropaneacetonitrile or methyl cyclopropylamide (II); acidifying the methyl cyclopropanecarboxylate, thereby obtaining 1-methyl cyclopropane carboxylic acid (I); and performing basic hydrolysis on methyl cyclopropaneacetonitrile or methyl cyclopropylamide, and acidifying to obtain 1-methyl cyclopropane carboxylic acid (I). The method disclosed by the invention is readily available in raw materials, mild in reaction conditions, convenient to operate, low in cost and high in purity of the obtained product and is a feasible preparation method.
CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS
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Page/Page column 104, (2011/12/14)
Therapeutic compounds are disclosed having the general formula (I) that are useful for the treatment of metabolic disorders, including type II diabetes. The compounds have activity as agonists of GPR119. Compounds having the stereochemistry of formula (la) may also demonstrate DPP-IV inhibitory activity.
PHOTOELECTRON SPECTRA AND MOLECULAR ORBITALS OF 1-METHYL-1-CYANOCYLOPROPANE AND 3-METHYL-3-CYANOCYCLOPROPENE
Plemenkov, V. V.,Redchenko, V. V.,Ermolaeva, L.V.,Bolesov, I. G.,Gritsenko, E. I.
, p. 184 - 187 (2007/10/02)
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