Formamide, N-2-pyrimidinyl- (6CI,9CI)

Base Information

• Chemical Name: Formamide, N-2-pyrimidinyl- (6CI,9CI)
• CAS No.: 31354-57-1
• Molecular Formula: C₅H₅N₃O
• Molecular Weight: 123.114
• Hs Code.: 2933599090
• Mol file: 31354-57-1.mol

Synonyms:2-(Formylamino)pyrimidine;N-(2-Pyrimidinyl)formamide; NSC 81210

Chemical Property of Formamide, N-2-pyrimidinyl- (6CI,9CI)

Chemical Property:

• Vapor Pressure: 0.00278mmHg at 25°C
• Melting Point: 168 °C(Solv: ethanol (64-17-5))
• Boiling Point: 285.6°Cat760mmHg
• PKA: 12.39±0.70(Predicted)
• Flash Point: 126.5°C
• PSA: 54.88000
• Density: 1.328g/cm³
• LogP: 0.75380

Purity/Quality:

99%min ^*data from raw suppliers

N-(2-Pyrimidinyl)-formamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Formamide, N-2-pyrimidinyl- (6CI,9CI)

There total 7 articles about Formamide, N-2-pyrimidinyl- (6CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-aminopyrimidine (109-12-6) + formic acid (64-18-6) → N-(pyrimidin-2-yl)formamide (31354-57-1)

Guidance literature:

With zinc(II) chloride; at 70 ℃; for 0.5h; neat (no solvent);

DOI:10.1016/j.tetlet.2009.10.006

Reference yield: 94.0%

2-(5'-imino-2'-imidazolin-1'-yl)pyrimidine (88945-45-3) → N-(pyrimidin-2-yl)formamide (31354-57-1)

Guidance literature:

With water; acid;

DOI:10.1016/S0040-4039(00)99884-8

Reference yield: 93.0%

2-aminopyrimidine (109-12-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N-(pyrimidin-2-yl)formamide (31354-57-1)

Guidance literature:

With potassium tert-butylate; at 25 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201900666

upstream raw materials:

2-aminopyrimidine

tris(formylamino)methane

2-(5'-imino-2'-imidazolin-1'-yl)pyrimidine

pyrographite

Refernces

• 1、 Tan, Zhiyong,Li, Zhenhua,Ma, Yao,Qin, Jinjing,Yu, Chuanming. "Potassium tert-Butoxide Prompted Highly Efficient Transamidation and Its Coordination Radical Mechanism". . p. 4538 - 4545. Retrieved 2019/07/18.
• 2、 -. "Oxazolo-pyrimidine derivatives". . . Retrieved 2008/06/13.