cyclic adenosine-5'-trimetaphosphate

Base Information

• Chemical Name: cyclic adenosine-5'-trimetaphosphate
• CAS No.: 53355-60-5
• Molecular Formula: C10H14N5O12P3
• Molecular Weight: 489.169
• Mol file: 53355-60-5.mol

Synonyms:Adenosine,5'-O-(4,6-dihydroxy-1,3,5,2,4,6-trioxatriphosphorinan-2-yl)-,P,P',P''-trioxide;1,3,5,2,4,6-Trioxatriphosphorinane, adenosine deriv.;Adenosine 5'-trimetaphosphate;Monoadenosine 5'-trimetaphosphate;

Chemical Property of cyclic adenosine-5'-trimetaphosphate

Chemical Property:

• Boiling Point: 831.4 °C at 760 mmHg
• Flash Point: 456.6 °C
• PSA: 277.33000
• Density: 2.78 g/cm³
• LogP: -0.00220

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cyclic adenosine-5'-trimetaphosphate

There total 4 articles about cyclic adenosine-5'-trimetaphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

adenosine-5'-triphosphate tetrakis-(tetrabutylammonium) salt (81926-41-2,90290-56-5,151146-02-0) → adenosine 5'-trimetaphosphate (53355-60-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In dimethyl sulfoxide; for 1h; Ambient temperature;

DOI:10.1021/jm00348a006

Reference yield:

C10H12Cl2N5O5P (34051-17-7) → adenosine 5'-trimetaphosphate (53355-60-5)

Guidance literature:

With tri-n-butylammonium phosphate; tributyl-amine; In N,N-dimethyl-formamide; at 0 ℃; for 0.0166667h;

DOI:10.1039/c39910001276

Reference yield:

adenosine (58-61-7) → adenosine 5'-trimetaphosphate (53355-60-5)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / various solvent(s) / 3 h / 0 °C

2: tri-n-butylammonium phosphate, tri-n-butylamine / dimethylformamide / 0.02 h / 0 °C

With tri-n-butylammonium phosphate; tributyl-amine; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1039/c39910001276

upstream raw materials:

C₁₀H₁₂Cl₂N₅O₅P

adenosine-5'-triphosphate tetrakis-(tetrabutylammonium) salt

adenosine

Downstream raw materials:

P¹,P⁶-di(adenosine-5') hexaphosphate

Diadenosine tetraphosphate

p¹,p⁵-di(adenosine 5'-)pentaphosphate

adenosine 5'-triphosphate

Refernces

• 1、 Mishra, Nrusingha C.,Broom, Arthur D.. "A Novel Synthesis of Nucleoside 5'-Triphosphates". . p. 1276 - 1277. Retrieved 2007/10/02.