1-methylhydrazinecarboxamide

Base Information

• Chemical Name: 1-methylhydrazinecarboxamide
• CAS No.: 22718-48-5
• Molecular Formula: C2H7 N3 O
• Molecular Weight: 89.0971
• Mol file: 22718-48-5.mol

Synonyms:Semicarbazide,2-methyl- (6CI,8CI); 2-Methylsemicarbazide; NSC 82193

Chemical Property of 1-methylhydrazinecarboxamide

Chemical Property:

• Vapor Pressure: 0.551mmHg at 25°C
• Boiling Point: 190.1°C at 760 mmHg
• Flash Point: 68.8°C
• Density: 1.215g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-methylhydrazinecarboxamide

There total 12 articles about 1-methylhydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trimethylsilyl isocyanate (1118-02-1) + methylhydrazine (60-34-4) → 2-methyl semicarbazide (22718-48-5)

Guidance literature:

trimethylsilyl isocyanate; methylhydrazine; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

In tetrahydrofuran; methanol; at 40 ℃; for 5h; Inert atmosphere;

DOI:10.1002/chem.201705030

Reference yield: 4.0%

potassium cyanate (590-28-3) + methylhydrazine (60-34-4) → 2-methyl semicarbazide (22718-48-5)

Guidance literature:

With hydrogenchloride; In water; at 110 ℃;

DOI:10.1039/c2cc31161e

Reference yield:

sodium isocyanate (917-61-3) + methylhydrazine (60-34-4) → 2-methyl semicarbazide (22718-48-5)

Guidance literature:

With hydrogenchloride; In water; at 0 - 20 ℃;

upstream raw materials:

1-methyl-1-nitrosourea

potassium cyanate

methylhydrazine sulfuric acid

methylhydrazine

Downstream raw materials:

2-Methylsemicarbazid-dicarbimidsaeure-(1,1)-bis-p-tolylester

2-Methyl-semicarbazid-di-carbimidsaeure-(1,1)-bis-(2,4-dimethyl-phenylester)

5-(difluoromethyl)-1,2-dihydro-2-methyl-3H-1,2,4-(triazol)-3-one

N-(benzyloxycarbonyl)glycyl-azaalanine-amide

Refernces

• 1、 Fesenko, Anastasia A.,Trafimova, Ludmila A.,Zimin, Maxim O.,Kuvakin, Alexander S.,Shutalev, Anatoly D.. "N2-Alkylation of semicarbazones. A general and efficient protocol for the synthesis of 2-alkylsemicarbazides from semicarbazide". . p. 176 - 189. Retrieved 2020/02/13.
• 2、 Ottersbach, Philipp A.,Schnakenburg, Gregor,Guetschow, Michael. "Induction of chirality: Experimental evidence of atropisomerism in azapeptides". supporting information; experimental part. p. 5772 - 5774. Retrieved 2012/08/28.