Alytesin, 2-L-glutamine-6-L-asparagine-

Base Information

• Chemical Name: Alytesin, 2-L-glutamine-6-L-asparagine-
• CAS No.: 31362-50-2
• Molecular Formula: C71H110 N24 O18 S
• Molecular Weight: 1619.87
• UNII: PX9AZU7QPK
• ChEMBL ID: CHEMBL437027
• NCI Thesaurus Code: C315
• Wikipedia: Bombesin
• Mol file: 31362-50-2.mol

Synonyms:Bombesin;Bombesin 14;Bombesin Dihydrochloride;Dihydrochloride, Bombesin

Chemical Property of Alytesin, 2-L-glutamine-6-L-asparagine-

Chemical Property:

• Appearance/Colour: While lyophilized powder.
• PKA: 13.04±0.46(Predicted)
• PSA: 711.43000
• Density: 1.5g/cm³
• LogP: 2.59880
• Storage Temp.: −20°C
• Solubility.: 0.05 M acetic acid: 20 mg/mL, clear, colorless
• XLogP3: -4.4
• Hydrogen Bond Donor Count: 23
• Hydrogen Bond Acceptor Count: 21
• Rotatable Bond Count: 52
• Exact Mass: 1618.81506393
• Heavy Atom Count: 114
• Complexity: 3410

Purity/Quality:

99% ^*data from raw suppliers

Bombesin ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NCC(=O)NC(CC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CC3=CN=CN3)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C4CCC(=O)N4
• Isomeric SMILES: C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]4CCC(=O)N4
• Uses: Gut tetradecapeptide with the ability to stimulate release of various hormones

Technology Process of Alytesin, 2-L-glutamine-6-L-asparagine-

There total 1 articles about Alytesin, 2-L-glutamine-6-L-asparagine- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + Fmoc-Val-OH (68858-20-8) + Fmoc-Leu-OH (35661-60-0) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine (71989-28-1) + N-fluoren-9-ylmethyloxycarbonyl-L-pyroglutamine (109425-56-1,106982-77-8) → Bombesin (31362-50-2)

Guidance literature:

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.583333h;

With piperidine; In N,N-dimethyl-formamide;

N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Val-OH; Fmoc-Leu-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; N-fluoren-9-ylmethyloxycarbonyl-L-pyroglutamine; Fmoc-His(pg)-OH; Fmoc-Trp(pg)-OH; Fmoc-Gln(pg)-OH; Fmoc-Asn(pg)-OH; Fmoc-Arg(pg)-OH; Further stages;

DOI:10.3390/ph11030065

upstream raw materials:

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Val-OH

Fmoc-Leu-OH

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Refernces