68858-20-8Relevant articles and documents
Self-assembly and anion-response of azobenzene-based L-valinamide derivative
Li, Kechang,Xue, Pengchong
, p. 206 - 212 (2018)
An azobenzene-based L-valinamide derivative was synthesized, and its gelation ability and self-assembly in organic solvents were investigated. Results suggested that it is an excellent gelator and formed organogels in many solvents, such as 3-pentanone, aniline, o-dichlorobenzene (ODCB), CH2Cl2, THF, ethanol, DMSO, and DMF. Its self-assembly in ODCB gel was studied. Transmission electron microscopic observation suggested that the gelator can self-assemble into one-dimensional nanofibers in the gel, and this phenomenon is driven by hydrogen bonding between amide units and π-π interaction between azobenzene moieties. With the increase in gelator concentration, the gel-to-sol phase transition temperature increased and the gelation time of the solvent shortened. Moreover, the gel exhibit anion response. A gel-to-sol phase transition was found after fluoride anion was added, exhibiting selective response to F?.
COMPOUNDS, COMPOSITIONS, METHODS, AND USES FOR TREATING CANCER AND IMMUNOLOGICAL DISORDERS
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Paragraph 0546; 0551-0552, (2020/02/06)
The present disclosure provides novel polypeptide-therapeutic compound or hormone-therapeutic compound conjugates using cleavable or non-cleavable linkers, whereby the polypeptide or hormone serves to target specific cells using receptor expression on the targeted cell to bind the ligand (polypeptide or hormone) carrying the therapeutic compound unlike antibody drug conjugates. Upon binding, the ligand and the therapeutic compound (multiples of the therapeutic compound in some embodiments) enter the cell by receptor-mediated endocytosis, and release drugs conjugated to the ligand by linkers, to interact with intracellular components to enhance, restore, or block a signal transduction process. The ligands for the polypeptide-therapeutic compound or hormone-therapeutic compound conjugates include, but are not limited to: cytokines, growth factors and hormones among other proteins with corresponding cell surface specific receptors. The disorders targeted by such polypeptide-therapeutic compound or hormone-therapeutic compound conjugates include, but are not limited to: immunological disorders (e.g., allergy and autoimmune disorders) and cancer.
Determination of Chemical and Enantiomeric Purity of α-Amino Acids and their Methyl Esters as N-Fluorenylmethoxycarbonyl Derivatives Using Amylose-derived Chiral Stationary Phases
Islam, Md. Fokhrul,Adhikari, Suraj,Paik, Man-Jeong,Lee, Wonjae
, p. 332 - 338 (2019/04/13)
Liquid chromatographic enantiomer separation and simultaneous determination of chemical and enantiomeric purity of α-amino acids and their methyl esters as N-fluorenylmethoxycarbonyl (FMOC) derivatives was performed on three covalently bonded type chiral stationary phases (CSPs) derived from amylose derivatives. The enantiomer separation of α-amino acid esters as N-FMOC derivatives was better than that of the corresponding acids, especially for CSP 1 and 2. Chemical impurities as the corresponding racemic acids present in several commercially available racemic amino acid methyl esters were observed to be 0.49–17.50%. Enantiomeric impurities of several commercially available L-amino acid methyl esters were found to be 0.03–0.58%, whereas chemical impurities as the corresponding racemic acids present in the same analytes were found to be 0.13–13.62%. This developed analytical method will be useful for the determination of chemical and enantiomeric purity of α-amino acids and/or esters as N-FMOC derivatives using amylose-derived CSPs.