o-Phenethylaniline

Base Information

• Chemical Name: o-Phenethylaniline
• CAS No.: 5697-85-8
• Molecular Formula: C14H15N
• Molecular Weight: 197.28
• Mol file: 5697-85-8.mol

Synonyms:[2-(2-Phenylethyl)phenyl]amine hydrochloride;1-(2-aminophenyl)-2-phenylethane;2-Amino-bibenzyl;2-Amino-dibenzyl;2-(2-phenylethyl)-benzenamine;2-phenethylaniline;bibenzyl-2-ylamine;Bibenzyl-2-ylamin;Benzenamine, 2-(2-phenylethyl)-;

Chemical Property of o-Phenethylaniline

Chemical Property:

• Vapor Pressure: 0.000319mmHg at 25°C
• Melting Point: 33°C
• Refractive Index: 1.6095 (estimate)
• Boiling Point: 320.4°Cat760mmHg
• PKA: 4.24±0.10(Predicted)
• Flash Point: 154.1°C
• PSA: 26.02000
• Density: 1.065g/cm³
• LogP: 3.63520

Purity/Quality:

99%min ^*data from raw suppliers

[2-(2-PHENYLETHYL)PHENYL]AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of o-Phenethylaniline

There total 43 articles about o-Phenethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-nitrostilbene (4714-25-4) → 2-(2-phenylethyl)aniline (5697-85-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃;

DOI:10.1016/j.bmc.2009.05.066

Reference yield: 90.0%

2-phenylethynylaniline (13141-38-3) → 2-(2-phenylethyl)aniline (5697-85-8)

Guidance literature:

With Wilkinson's catalyst; N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; hydrogen; In toluene; at 20 ℃; for 16h; under 1125.11 Torr;

DOI:10.1002/anie.201506216

Reference yield: 25.0%

2-(2-Phenylethyl)phenyl azide (164398-51-0) → 2-phenyl-indole (948-65-2) + 2-phenyl-2,3-dihydro-1H-indole (26216-91-1,917377-78-7) + 2-(2-phenylethyl)aniline (5697-85-8)

Guidance literature:

2-(2-Phenylethyl)phenyl azide; With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In benzene; at 25 ℃; for 16h; Inert atmosphere;

With silica gel;

DOI:10.1021/ol901317j

upstream raw materials:

(Z)-2-nitrostilbene

(E)-2-nitrostilbene

N-(2-phenethylphenyl)benzamide

2-methoxymethylaniline

Downstream raw materials:

C₂₂H₁₆N₂O₄

C₂₂H₁₆N₂O₄

(E)-N-[3-chloro-1-ethylpyridin-4(1H)-ylidene]-2-phenethylaniline trifluoromethanesulfonate

4,5,6,7-tetrachloro-N-[2'-(2-phenylethyl)phenyl]phthalimide

Refernces

• 1、 Chen, Chun-Han,Chuang, Hsun-Yueh,Hung, To-Yu,Lai, Mei-Jung,Liao, Yu-Hsuan,Lin, Mei-Hsiang,Liou, Jing-Ping,Liu, Yi-Min,Wu, Wei-Cheng. "Design, synthesis, and evaluation of N-phenyl-4-(2-phenylsulfonamido)-benzamides as microtubule-targeting agents in drug-resistant cancer cells, displaying HDAC inhibitory response". . . Retrieved 2020/03/13.
• 2、 Alt, Isabel T.,Guttroff, Claudia,Plietker, Bernd. "Iron-Catalyzed Intramolecular Aminations of C(sp3)?H Bonds in Alkylaryl Azides". supporting information. p. 10582 - 10586. Retrieved 2017/08/22.