5,7-dimethoxy-4'-hydroxyflavone

Base Information

• Chemical Name: 5,7-dimethoxy-4'-hydroxyflavone
• CAS No.: 16290-50-9
• Molecular Formula: C17H14 O5
• Molecular Weight: 298.295
• Hs Code.: 2914509090
• Mol file: 16290-50-9.mol

Synonyms:Flavone,4'-hydroxy-5,7-dimethoxy- (6CI,7CI,8CI); 4'-Hydroxy-5,7-dimethoxyflavone;5,7-Dimethoxy-4'-hydroxyflavone; Apigenin 5,7-dimethyl ether

Chemical Property of 5,7-dimethoxy-4'-hydroxyflavone

Chemical Property:

• Boiling Point: 532.4°Cat760mmHg
• Flash Point: 200.3°C
• PSA: 68.90000
• Density: 1.321g/cm³
• LogP: 3.18280

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7-dimethoxy-4'-hydroxyflavone

There total 15 articles about 5,7-dimethoxy-4'-hydroxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C20H18O5 (1167577-15-2) → 3-(4-hydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one (16290-50-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; at 90 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.04.043

Reference yield: 85.0%

2-[4-(benzyloxy)phenyl]-5,7-dimethoxy-4H-chromen-4-one (22812-15-3) → 3-(4-hydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one (16290-50-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1016/j.ejmech.2020.112677

Reference yield: 10.0%

Dimethyl-chrysin (21392-57-4) → 2-(3-hydroxy-phenyl)-5,7-dimethoxy-chromen-4-one (743430-86-6) + 3-(4-hydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one (16290-50-9) + 2-(3,4-dihydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one (90363-40-9)

Guidance literature:

With Beauveria bassiana KCh J_1.5; for 168h;

DOI:10.1021/acs.jafc.1c00136

upstream raw materials:

2-(4-aminophenyl)-5,7-dimethoxy-4H-chromen-4-one

2-[4-(benzyloxy)phenyl]-5,7-dimethoxy-4H-chromen-4-one

p-benzyloxybenzaldehyde

(E)-3-(4-(benzyloxy)phenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one

Downstream raw materials:

2-(4-acetoxy-phenyl)-5,7-dimethoxy-chromen-4-one

genkwanin

C₃₅H₂₈O₁₀

2-(4-(2-bromoethoxy)phenyl)-5,7-dimethoxychromen-4-one

Refernces

• 1、 Wei, Mingming,Xie, Maodun,Zhang, Zhen,Wei, Yujiao,Zhang, Juan,Pan, Hongli,Li, Benlong,Wang, Jingjing,Song, Yang,Chong, Chuangke,Zhao, Rui,Wang, Jiefu,Yu, Li,Yang, Guang,Yang, Cheng. "Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer". . . Retrieved 2020/08/21.
• 2、 Lin, An-Shen,Nakagawa-Goto, Kyoko,Chang, Fang-Rong,Yu, Donglei,Morris-Natschke, Susan L.,Wu, Chin-Chung,Chen, Shu-Li,Wu, Yang-Chang,Lee, Kuo-Hsiung. "First total synthesis of protoapigenone and its analogues as potent cytotoxic agents". . p. 3921 - 3927. Retrieved 2008/02/10.