4',5-DIHYDROXY-7-METHOXYFLAVONE

Base Information

• Chemical Name: 4',5-DIHYDROXY-7-METHOXYFLAVONE
• CAS No.: 437-64-9
• Molecular Formula: C16H12 O5
• Molecular Weight: 284.268
• Hs Code.: 29329990
• Mol file: 437-64-9.mol

Synonyms:Flavone,4',5-dihydroxy-7-methoxy- (7CI,8CI); Genkwanin (6CI);4',5-Dihydroxy-7-methoxyflavone; 5,4'-Dihydroxy-7-methoxyflavone;7-Methylapigenin; 7-O-Methylapigenin; Apigenin 7-O-methyl ether; Apigenin7-methyl ether; Gengkwanin; Genquanin; Henquanin; Puddumetin

Chemical Property of 4',5-DIHYDROXY-7-METHOXYFLAVONE

Chemical Property:

• Appearance/Colour: Orange Powder
• Melting Point: 290-292°C
• Boiling Point: 546.5°Cat760mmHg
• PKA: 6.36±0.40(Predicted)
• Flash Point: 209.7°C
• PSA: 79.90000
• Density: 1.42g/cm³
• LogP: 2.87980
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• Solubility.: Acetone (Very Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Genkwanin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-24/25-22-37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An antitumor constituent from the leaves of Aquilaria sinensis.

Technology Process of 4',5-DIHYDROXY-7-METHOXYFLAVONE

There total 52 articles about 4',5-DIHYDROXY-7-METHOXYFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4',5,-diacetoxy-7-methoxyflavone (16280-23-2) → genkwanin (437-64-9)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 1h;

DOI:10.3987/COM-18-S(F)17

Reference yield: 80.0%

4',5,7-trimethoxyflavone (5631-70-9) → genkwanin (437-64-9)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.organomet.9b00629

Reference yield: 75.0%

1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (32274-67-2) → genkwanin (437-64-9)

Guidance literature:

With iodine; In dimethyl sulfoxide; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.1002/cbdv.201400181

upstream raw materials:

5,4'-dihydroxy-7-methoxyflavanone

3-(4-hydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one

2-(4-benzyloxy-phenyl)-5-hydroxy-7-methoxy-chromen-4-one

protogenkwanin

Downstream raw materials:

5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

5-benzoyloxy-2-(4-benzoyloxy-phenyl)-7-methoxy-chromen-4-one

4',5,-diacetoxy-7-methoxyflavone

protogenkwanone

Refernces

• 1、 Choe, Jung-Won,Heo, Hee-Young,Jung, Se-Hui,Kim, Jaehyun,Lee, Kooyeon. "Anti‐melanogenic properties of velutin and its analogs?". . . Retrieved 2021/06/03.
• 2、 Mokar, Bhanudas Dattatray,Yi, Chae S.. "Scope and Mechanism of the Ruthenium-Catalyzed Dehydrative C-H Coupling of Phenols with α,β-Unsaturated Carbonyl Compounds: Expedient Synthesis of Chromene and Benzoxacyclic Derivatives". . p. 4625 - 4632. Retrieved 2019/12/24.