2-Isopropenylpyridine

Base Information

• Chemical Name: 2-Isopropenylpyridine
• CAS No.: 6515-13-5
• Molecular Formula: C8H9 N
• Molecular Weight: 119.166
• Hs Code.: 2933399090
• European Community (EC) Number: 229-404-7
• DSSTox Substance ID: DTXSID20983720
• Nikkaji Number: J225.163I
• Wikidata: Q82970660
• Mol file: 6515-13-5.mol

Synonyms:2-(prop-1-en-2-yl)pyridine;2-Isopropenylpyridine;6515-13-5;2-prop-1-en-2-ylpyridine;2-(1-Propen-2-yl)pyridine;EINECS 229-404-7;MFCD18384263;Pyridine, (1-methylethenyl)-;SCHEMBL177744;2-(1-methylethenyl)-Pyridine;DTXSID20983720;AKOS013991702;AS-57578;SY225338;CS-0059949;EN300-195545;W17791;A917831;F1967-3030

Chemical Property of 2-Isopropenylpyridine

Chemical Property:

• Vapor Pressure: 1.54mmHg at 25°C
• Boiling Point: 175.4°C at 760 mmHg
• Flash Point: 56.5°C
• PSA: 23.47000
• Density: 0.927g/cm³
• LogP: 3.31460
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 119.073499291
• Heavy Atom Count: 9
• Complexity: 107

Purity/Quality:

98%Min ^*data from raw suppliers

2-(prop-1-en-2-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=C)C1=CC=CC=N1

Technology Process of 2-Isopropenylpyridine

There total 10 articles about 2-Isopropenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-acetylpyridine (1122-62-9) + methyl-triphenylphosphonium iodide (2065-66-9) → 2-isopropenylpyridine (6515-13-5)

Guidance literature:

methyl-triphenylphosphonium iodide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

2-acetylpyridine; In tetrahydrofuran; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1021/jo900292b

Reference yield: 55.0%

2-acetylpyridine (1122-62-9) + Methyltriphenylphosphonium bromide (1779-49-3) → 2-isopropenylpyridine (6515-13-5)

Guidance literature:

Methyltriphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.25h; Schlenk technique;

2-acetylpyridine; In tetrahydrofuran; at 20 ℃; for 0.75h; Schlenk technique;

DOI:10.1021/ja507902z

Reference yield: 8.0%

2-bromo-pyridine (109-04-6) + 2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (126726-62-3) → 2-isopropenylpyridine (6515-13-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 90 ℃; for 24h;

DOI:10.1016/j.tetlet.2018.11.013

upstream raw materials:

formaldehyd

2-Ethylpyridine

2-(pyridine-2-yl)propan-2-ol

2-acetylpyridine

Downstream raw materials:

2-(1-phenylethenyl)-1-(3-methyl-3-butenyl)pyridinium triflate

2-acetylpyridine

5-(pyridine-2-yl)pyrimidine

1,4-bis(2,2':6',2''-terpyridin-4-yl)benzene

Refernces

• 1、 -. "METHOD FOR OXIDATIVE CLEAVAGE OF COMPOUNDS WITH UNSATURATED DOUBLE BOND". Paragraph 0027-0029. . Retrieved 2021/07/10.
• 2、 -. "METHOD FOR OXIDATIVE CLEAVAGE OF COMPOUNDS WITH UNSATURATED DOUBLE BOND". Paragraph 0024-0025; 0030. . Retrieved 2021/03/19.