Camphorquinone-10-sulfonic acid

Base Information

• Chemical Name: Camphorquinone-10-sulfonic acid
• CAS No.: 73413-79-3
• Molecular Formula: C₁₀H₁₄O₅S
• Molecular Weight: 246.284
• Hs Code.: 2914790090
• European Community (EC) Number: 635-299-2
• Nikkaji Number: J2.319.829K
• Mol file: 73413-79-3.mol

Synonyms:7,7-dimethylbicyclo(2.2.1)heptane-2,3-dione-1-methanesulfonic acid;camphorquinone-10-sulfonic acid

Chemical Property of Camphorquinone-10-sulfonic acid

Chemical Property:

• Melting Point: 155-157°C
• PSA: 106.12000
• Density: 1.44g/cm³
• LogP: 1.46510
• Storage Temp.: 2-8°C
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 246.05619472
• Heavy Atom Count: 16
• Complexity: 470

Purity/Quality:

99% ^*data from raw suppliers

Camphorquinone-10-sulfonic acid hydrate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1(C2CCC1(C(=O)C2=O)CS(=O)(=O)O)C
• Uses: Camphorquinone-10-sulfonic acid is a crystalline water-soluble reagent that is useful for specific, reversible modification of the guanidino groups of arginine residues. Suitable for use with small arginine-containing molecules.

Technology Process of Camphorquinone-10-sulfonic acid

There total 3 articles about Camphorquinone-10-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(1S)-10-camphorsulfonic acid (3144-16-9,61380-66-3) → 10-camphorquinone sulfonic acid (73413-79-3)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; Reflux;

Reference yield: 60.0%

camphor-10-sulfonic acid (76-26-6,3144-16-9,5872-08-2,35963-20-3,61380-66-3) → 7,7-dimethyl-2,3-dioxo-bicyclo[2.2.1]heptane-4-methanesulfonic acid (367522-55-2,73413-79-3)

Guidance literature:

With selenium(IV) oxide; In ethanol; at 150 ℃; for 1.25h; microwave irradiation;

DOI:10.1080/00397910500501557

Reference yield: 26.6%

DL camphor-10-thiazine dioxide (104319-35-9) → 7,7-dimethyl-2,3-dioxo-bicyclo[2.2.1]heptane-4-methanesulfonic acid (367522-55-2,73413-79-3) + 7,7-dimethyl-2,3-dioxo-bicyclo[2.2.1]heptane-4-methanesulfonamide + Camphorquinone (2767-84-2,10334-26-6,10373-78-1,71074-96-9,105309-30-6,465-29-2) + (-)-(3-oxo-camphorsulphonyl)imine (191212-13-2)

Guidance literature:

With selenium(IV) oxide; In water; at 150 ℃; for 1.25h; Further byproducts given; microwave irradiation;

DOI:10.1080/00397910500501557

upstream raw materials:

camphor-10-sulfonic acid

DL camphor-10-thiazine dioxide

(1S)-10-camphorsulfonic acid

Downstream raw materials:

camphorquinone-10-sulfonyl chloride

Refernces

• 1、 -. "POLYMERIZABLE DENTAL MATERIAL". Paragraph 0066; 0067; 0085. . Retrieved 2017/03/28.