2,5-DIMETHYLPYRAZOLO(1,5-A)PYRIMIDIN-7-ONE

Base Information

• Chemical Name: 2,5-DIMETHYLPYRAZOLO(1,5-A)PYRIMIDIN-7-ONE
• CAS No.: 98488-10-9
• Molecular Formula: C₈H₉N₃O
• Molecular Weight: 163.179
• Hs Code.: 2933990090
• Mol file: 98488-10-9.mol

Synonyms:KM 00085

Chemical Property of 2,5-DIMETHYLPYRAZOLO(1,5-A)PYRIMIDIN-7-ONE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 252 °C
• Boiling Point: 266.3°Cat760mmHg
• Flash Point: 114.9°C
• PSA: 47.25000
• Density: 1.35g/cm³
• LogP: 0.76340

Purity/Quality:

98%min ^*data from raw suppliers

2,5-Dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-7-one ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

Useful:

Technology Process of 2,5-DIMETHYLPYRAZOLO(1,5-A)PYRIMIDIN-7-ONE

There total 3 articles about 2,5-DIMETHYLPYRAZOLO(1,5-A)PYRIMIDIN-7-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl acetoacetate (141-97-9) + 3-amino-5-methylpyrazole (31230-17-8) → 2,7-dimethyl-1,4-dihydropyrazolo[1,5-a]pyrimidin-4-one (98488-10-9)

Guidance literature:

at 140 - 150 ℃; for 3h;

DOI:10.1023/B:COHC.0000008268.94940.5c

Reference yield: 93.0%

3-methyl-5-aminopyrazole (31230-17-8) + ethyl acetoacetate (141-97-9) → 2,7-dimethyl-1,4-dihydropyrazolo[1,5-a]pyrimidin-4-one (98488-10-9)

Guidance literature:

In acetic acid; at 71 - 93 ℃;

DOI:10.1016/j.ejmech.2016.09.073

Reference yield: 82.0%

acetoacetic acid methyl ester (105-45-3) + 3-amino-5-methylpyrazole (31230-17-8) → 2,7-dimethyl-1,4-dihydropyrazolo[1,5-a]pyrimidin-4-one (98488-10-9)

Guidance literature:

In acetic acid; at 120 ℃; for 16h; Reflux;

DOI:10.1016/j.bmc.2015.10.021

upstream raw materials:

3-methyl-5-aminopyrazole

ethyl acetoacetate

3-amino-5-methylpyrazole

acetoacetic acid methyl ester

Downstream raw materials:

C₁₄H₁₄N₄

7-chloro-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine

Refernces

• 1、 Azeredo, Luís Felipe S.P.,Coutinho, Julia P.,Jabor, Valquiria A.P.,Feliciano, Patricia R.,Nonato, Maria Cristina,Kaiser, Carlos R.,Menezes, Carla Maria S.,Hammes, Amanda S.O.,Caffarena, Ernesto Raul,Hoelz, Lucas V.B.,de Souza, Nicolli B.,Pereira, Glaécia A.N.,Cerávolo, Isabela P.,Krettli, Antoniana U.,Boechat, Nubia. "Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors". . p. 72 - 83. Retrieved 2016/10/25.
• 2、 -. "THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS". Page/Page column 14. . Retrieved 2008/06/13.