31230-17-8 Usage
Description
3-Amino-5-methylpyrazole is a white to light yellow crystalline compound with significant applications in various chemical and pharmaceutical processes. It is known for its ability to form beta-sheet templates, which are crucial in the study of protein folding and interactions.
Uses
Used in Chemical Synthesis:
3-Amino-5-methylpyrazole is used as a beta-sheet template for investigating its interaction with ferrocenoyl-dipeptides. This application is essential in understanding the structural and functional aspects of these peptides, which can be vital in the development of new drugs and therapies.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-Amino-5-methylpyrazole is used in the synthesis of 4-aryl-3,7,7-trimethyl-2,4,6,7,8,9-hexahydropyrazolo[3,4-b]quinolin-5-ones. These compounds have potential applications in the development of new drugs, particularly in the treatment of various diseases.
Used in Chemical Property Studies:
The complexation of the aminoand carboxyl-protected tripeptide with 3-amino-5-methylpyrazole has been studied using low-temperature NMR experiments in a freonic solvent. This research helps in understanding the chemical properties and behavior of these compounds, which can be useful in the design and synthesis of new molecules with specific functions.
Additionally, 3-Amino-5-methylpyrazole can react with 4-Ethoxymethylene-2-phenyl-4H-oxazol-5-one to produce N-(2-Methyl-7-oxo-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-6-yl)-benzamide, which may have potential applications in the development of new chemical compounds and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 31230-17-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,2,3 and 0 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 31230-17:
(7*3)+(6*1)+(5*2)+(4*3)+(3*0)+(2*1)+(1*7)=58
58 % 10 = 8
So 31230-17-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H7N3/c1-3-2-4(5)7-6-3/h2H,1H3,(H3,5,6,7)
31230-17-8Relevant articles and documents
The Suzuki-Miyaura Cross-Coupling Reaction of Halogenated Aminopyrazoles: Method Development, Scope, and Mechanism of Dehalogenation Side Reaction
Jedinák, Luká?,Zátopková, Renáta,Zemánková, Hana,?ustková, Alena,Canka?, Petr
supporting information, p. 157 - 169 (2017/04/26)
The efficient Suzuki-Miyaura cross-coupling reaction of halogenated aminopyrazoles and their amides or ureas with a range of aryl, heteroaryl, and styryl boronic acids or esters has been developed. The method allowed incorporation of problematic substrates: aminopyrazoles bearing protected or unprotected pyrazole NH, as well as the free amino or N-amide group. Direct comparison of the chloro, bromo, and iodopyrazoles in the Suzuki-Miyaura reaction revealed that Br and Cl derivatives were superior to iodopyrazoles, as a result of reduced propensity to dehalogenation. Moreover, the mechanism and factors affecting the undesired dehalogenation side reaction were revealed.
Synthesis of 4-acetyl-5(3)-amino-3(5)-methylpyrazoles and pyrazolopyrimidines from diacetylketene N,S-acetal
Dorokhov, V. A.,Komkov, A. V.,Ugrak, B. I.
, p. 1364 - 1368 (2007/10/02)
Isomeric 4-acetyl-5-amino-3-methyl- and 4-acetyl-3-amino-5-methylpyrazoles (2, 3) were formed in the reaction of hydrazones with 3-pentan-2,4-dione (1) (diacetylketene N,S-acetal).Pyrazolopyrimidines (5a,b) were synthesized by condensation of 4-acetyl-5-amino-1,3-dimethylpyrazole (2a) with amide dimethylacetals followed by treatment with ammonium acetate.The structures of the compounds obtained were confirmed by 13C and 15N NMR spectroscopy. - Key words: diacetylketene N,S-acetal; hydrazines; 4-acetyl-5(3)-aminopyrazoles; amide acetals; pyrazolopyrimidines.
