1780-72-9 Usage
General Description
4-Bromo-5-methyl-1H-pyrazol-3-amine is a chemical compound belonging to the class of organic compounds known as aminopyrazoles. These are organic compounds that contain an amino group attached to a pyrazole ring. Pyrazole is a five-membered aromatic ring with two nitrogen atoms and three carbon atoms. The presence of bromine and a methyl group in the compound contributes to its reactivity and other physical properties. Specific information about its applications, potential hazards, and safe handling methods are typically provided by the manufacturer or supplier, as its properties can vary depending on its specific form and concentration.
Check Digit Verification of cas no
The CAS Registry Mumber 1780-72-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,8 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1780-72:
(6*1)+(5*7)+(4*8)+(3*0)+(2*7)+(1*2)=89
89 % 10 = 9
So 1780-72-9 is a valid CAS Registry Number.
1780-72-9Relevant articles and documents
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Dziomko,Berestevich
, (1978)
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Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines
Abe, Masahito,Seto, Mabel,Gogliotti, Rocco G.,Loch, Matthew T.,Bollinger, Katrina A.,Chang, Sichen,Engelberg, Eileen M.,Luscombe, Vincent B.,Harp, Joel M.,Bubser, Michael,Engers, Darren W.,Jones, Carrie K.,Rodriguez, Alice L.,Blobaum, Anna L.,Conn, P. Jeffrey,Niswender, Colleen M.,Lindsley, Craig W.
supporting information, p. 1110 - 1115 (2017/10/18)
Herein, we report the structure-activity relationships within a series of mGlu7 PAMs based on a pyrazolo[1,5-a]pyrimidine core with excellent CNS penetration (Kps > 1 and Kp,uus > 1). Analogues in this series proved to dis
