5-nitrothiophene-2-carboxamide

Base Information

• Chemical Name: 5-nitrothiophene-2-carboxamide
• CAS No.: 5832-00-8
• Molecular Formula: C5H4N2O3S
• Molecular Weight: 172.1619
• Hs Code.: 2934999090
• Mol file: 5832-00-8.mol

Synonyms:5-Nitro-thiophen-2-carbonsaeure-amid;CCG-1823;5-nitrothiophen-2-carboxamide;2-carbamoyl-5-nitro-thiophene;5-nitro-thiophene-2-carboxylic acid amide;5-Nitro-thiophene-2-carboxamide;5-nitrothiophene carboxamide;

Chemical Property of 5-nitrothiophene-2-carboxamide

Chemical Property:

• Vapor Pressure: 0.00013mmHg at 25°C
• Boiling Point: 334.2°Cat760mmHg
• Flash Point: 155.9°C
• PSA: 117.15000
• Density: 1.572g/cm³
• LogP: 1.97870

Purity/Quality:

99%min ^*data from raw suppliers

5-Nitrothiophene-2-carboxamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-nitrothiophene-2-carboxamide

There total 4 articles about 5-nitrothiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

thiophene-2-carbonitrile (1003-31-2) → 5-nitrothiophene-2-carboxamide (5832-00-8) + 4-nitrothiophene-2-carboxamide (36050-08-5)

Guidance literature:

With sulfuric acid; potassium nitrate; for 16h; Ambient temperature;

DOI:10.1002/(SICI)1099-1344(199611)38:11<1015::AID-JLCR917>3.0.CO;2-6

Reference yield:

5-nitrothiophene-2-carboxylic acid (6317-37-9) → 5-nitrothiophene-2-carboxamide (5832-00-8)

Guidance literature:

With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

5-nitro-2-thienyl cyanide (16689-02-4) → 5-nitrothiophene-2-carboxamide (5832-00-8)

Guidance literature:

With sulfuric acid;

upstream raw materials:

5-nitro-2-thienyl cyanide

5-nitrothiophene-2-carbonyl chloride

thiophene-2-carbonitrile

5-nitrothiophene-2-carboxylic acid

Downstream raw materials:

5-(phenyloxycarbonylamino)thiophene-2-carboxamide

5-aminothiophene-2-carboxylic acid amide

Refernces

• 1、 -. "INHIBITORS OF JANUS KINASES". Page/Page column 102. . Retrieved 2009/01/23.