2-(2-Chloroethyl)-1-methylpyrrolidine

Base Information

• Chemical Name: 2-(2-Chloroethyl)-1-methylpyrrolidine
• CAS No.: 54777-54-7
• Molecular Formula: C₇H₁₄ClN
• Molecular Weight: 147.648
• Mol file: 54777-54-7.mol

Synonyms:1-Methyl-2-(2-chloroethyl)pyrrolidine;2-(2-Chloroethyl)-1-methylpyrrolidine;NSC 141817;

Chemical Property of 2-(2-Chloroethyl)-1-methylpyrrolidine

Chemical Property:

• Vapor Pressure: 0.849mmHg at 25°C
• Melting Point: 120-122 °C(Solv: ethyl acetate (141-78-6))
• Refractive Index: 1.462
• Boiling Point: 181.5 °C at 760 mmHg
• PKA: 10.13±0.40(Predicted)
• Flash Point: 63.6 °C
• PSA: 3.24000
• Density: 0.992 g/cm³
• LogP: 1.64740

Purity/Quality:

99% ^*data from raw suppliers

2-(2-CHLOROETHYL)-1-METHYLPYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(2-Chloroethyl)-1-methylpyrrolidine is an intermediate used in synthesis of SIB 1553A Hyrdrochloride (S411000).

Technology Process of 2-(2-Chloroethyl)-1-methylpyrrolidine

There total 4 articles about 2-(2-Chloroethyl)-1-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(1-methyl-2-pyrrolidine)ethanol (67004-64-2) → 2-(2-chloro-ethyl)-1-methyl-pyrrolidine (54777-54-7,61771-17-3,63527-58-2,67529-19-5)

Guidance literature:

With thionyl chloride; In dichloromethane; at 40 - 50 ℃; for 2h; Inert atmosphere;

Reference yield:

2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride (56824-22-7) → 2-(2-chloro-ethyl)-1-methyl-pyrrolidine (54777-54-7,61771-17-3,63527-58-2,67529-19-5)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

chloroform (67-66-3,8013-54-5) → 2-(2-chloro-ethyl)-1-methyl-pyrrolidine (54777-54-7,61771-17-3,63527-58-2,67529-19-5)

Guidance literature:

With hydrogenchloride; anschliessenden Erwaermen mit Thionylchlorid;

DOI:10.1002/hlca.19580410420

upstream raw materials:

chloroform

2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride

2-(1-methyl-2-pyrrolidine)ethanol

Downstream raw materials:

1-allyl-2-[2-methoxy 3,5-dichlorophenoxyethyl]pyrrolidine fumarate

2-(4-bromo-phenyl)-4-(1-methyl-pyrrolidin-2-yl)-butyronitrile

Refernces

• 1、 -. "Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them". Page/Page column 57. . Retrieved 2008/06/13.