67004-64-2Relevant articles and documents
Novel process for preparing 1-methyl-2-(2-hydroxyethyl)pyrrolidine
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, (2020/03/05)
The present invention relates to a method for synthesizing 1-methyl-2-(2-hydroxyethyl)pyrrolidine, which is useful as an intermediate of a pharmaceutical. More specifically, the present invention relates to a novel synthesis method which uses metal borohydride as a reducing agent in a process of manufacturing 1-methyl-2-(2-hydroxyethyl)pyrrolidine, which is a target substance, from methyl (2E/Z)-2-(1-methylpyrrolidinyridin-2-ylidene)acetate, wherein the methyl (2E/Z)-2-(1-methylpyrrolidinyridin-2-ylidene)acetate is reduced in two stages sequentially, thereby being able to obtain the target substance with a safe process and cheap cost compared to an existing method.COPYRIGHT KIPO 2020
Biomimetic oxidation of clemastine fumarate
Froehlich,Pietzyk,Smolinka,Goeber
, p. 409 - 414 (2007/10/03)
The reaction of clemastine fumarate (1) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride (MnTPFPPCl)/imidazole/hydrogen peroxide in a mixture of dichlormethane/methanol affords several metabolites. These compounds are products of O-dealkylation, N-demethylation, N-oxidation and separation of water. The reaction of 1 in aqueous solution with manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)-β-tetrasulfonat oporphyrin chloride (MnTPFPS4PCl) as catalyst additional generates products of aromatic hydroxylation. Products were identified by TLC, UV, and MS. Thereby we found a close conformity with rat metabolism.