60307-26-8

Basic information

• Product Name: (2R)-1-Methyl-2-Pyrrolidineethanol
• Synonyms: (2R)-1-Methyl-2-Pyrrolidineethanol;(R)-2-(1-Methylpyrrolidin-2-yl)ethanol;2-[(2R)-1-methylpyrrolidin-2-yl]ethanol
• CAS NO: 60307-26-8
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2001
• Mol File: 60307-26-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R)-1-Methyl-2-Pyrrolidineethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-1-Methyl-2-Pyrrolidineethanol(60307-26-8)
• EPA Substance Registry System: (2R)-1-Methyl-2-Pyrrolidineethanol(60307-26-8)

Safety Data

• Hazardous Substances Data: 60307-26-8(Hazardous Substances Data)

Usage

Description

(2R)-1-Methyl-2-Pyrrolidineethanol is a chiral pyrrolidine derivative characterized by its stereochemical configuration, with a methyl group attached to the second carbon and an ethanol group attached to the first carbon of the pyrrolidine ring. (2R)-1-Methyl-2-Pyrrolidineethanol is commonly utilized as a building block in organic synthesis and pharmaceutical research, offering potential applications in drug development and medicinal chemistry. Its unique structure and properties also suggest possible biological activity, making it a candidate for further exploration as a pharmacological agent.

Uses

Used in Pharmaceutical Research:
(2R)-1-Methyl-2-Pyrrolidineethanol is used as a building block in pharmaceutical research for its potential role in drug development and medicinal chemistry. Its unique stereochemistry and functional groups make it a valuable component in the design and synthesis of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, (2R)-1-Methyl-2-Pyrrolidineethanol is employed as a versatile intermediate for the creation of various complex organic molecules. Its structural features allow for multiple synthetic pathways, facilitating the production of a wide range of compounds with diverse applications.
Used in Drug Development:
(2R)-1-Methyl-2-Pyrrolidineethanol is utilized in drug development due to its potential biological activity. Its chiral nature and functional groups may contribute to the discovery of new pharmacological agents with specific therapeutic effects.
Used in Medicinal Chemistry:
In medicinal chemistry, (2R)-1-Methyl-2-Pyrrolidineethanol serves as a key component in the design and optimization of drug candidates. Its stereochemistry and chemical properties can be leveraged to enhance the potency, selectivity, and pharmacokinetic properties of new drugs.
Used in Biological Research:
(2R)-1-Methyl-2-Pyrrolidineethanol may also be used in biological research to explore its potential as a pharmacological agent. Its unique structure could provide insights into the interactions between molecules and biological targets, contributing to the advancement of our understanding of drug action and the development of new therapeutic strategies.

Upstream product

• 67004-64-2 2-(1-methyl-2-pyrrolidine)ethanol 
• 1352748-96-9 (S)-ethyl 2-(2-hydroxyethyl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 101555-60-6 2-(R)-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 107784-11-2 ((R)-1-Formyl-pyrrolidin-2-yl)-acetic acid ethyl ester 
• 107784-09-8 [(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-acetic acid ethyl ester 
• 200397-90-6 1-<1'-(S)-phenylethyl>-2-(ethoxycarbonylmethylidene)pyrrolidine 
• 107870-33-7 (R)-Pyrrolidin-2-yl-acetic acid ethyl ester 

Downstream Products

• 67499-71-2 (+)-(R)-2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride 

Relevant articles and documents

Resolution method of clemastine fumarate intermediate

The invention relates to the technical field of raw material medicine synthesis, and discloses a resolution method of a clemastine fumarate intermediate. The invention discloses a resolution method ofa clemastine fumarate intermediate. The used resolving agent is malic acid and bis(p-methylbenzoyl) tartaric acid, and the two resolving agents are D-type or L-type or one of D and L racemates, wherein the molar ratio of the using amount of the resolving agents to N-methyl-2 drops (2-hydroxyethyl) pyrrolidine is 1.0-2.0, and preferably, the molar multiple of the resolving agents is 1.0-1.3. The invention discloses a resolution method of a clemastine fumarate intermediate. After the N-methyl-2 (2-ethoxyl) pyrrolidine is resoluted, the yield can be stabilized above 48%. The method has the advantages of simple operation, good chiral purity, strong operationality, easy industrialization, solving of the problems of high production cost and large resolution technology difficulty of the synthesis method reported in literature, solving of the problems of increase of the production cost and the resolution technology difficulty caused by the first synthesis and the second chiral resolution, wide development space, and high promotion value.

Asymmetric synthesis of H1 receptor antagonist (R,R)-clemastine

The first asymmetric synthesis of (R,R)-clemastine (1) has been accomplished by the coupling of (R)-tertiary alcohol 2 and (R)-chloroethylpyrrolidine 3 via O-alkylation. (R)-Tertiary alcohol 2 was synthesized by stereoselective alkylation of chiral α-benz

SUBSTITUTED BENZHYDRYLETHERS

Disclosed herein are substituted benzhydrylethers of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of their use thereof.