Dimethyl DL-Glutamate Hydrochloride

Base Information

• Chemical Name: Dimethyl DL-Glutamate Hydrochloride
• CAS No.: 23150-65-4
• Molecular Formula: C7H14ClNO4
• Molecular Weight: 211.645
• Hs Code.: 29224999
• NSC Number: 83254
• UNII: 16247QSY33
• DSSTox Substance ID: DTXSID40388975
• Wikidata: Q27251762
• Mol file: 23150-65-4.mol

Synonyms:13515-99-6;Dimethyl DL-Glutamate Hydrochloride;dimethyl 2-aminopentanedioate hydrochloride;H-DL-Glu(OMe)-OMe.HCl;H-DL-Glu(Ome)-OMe;dimethyl 2-aminopentanedioate;hydrochloride;Glutamic acid, dimethyl ester, hydrochloride;UNII-16247QSY33;DL-Glutamic acid, dimethyl ester, hydrochloride;Glutamic acid, dimethyl ester, hydrochloride, DL-;16247QSY33;Glutamic acid, 1,5-dimethyl ester, hydrochloride (1:1);DIMETHYL 2-AMINOPENTANEDIOATE HCL;H-Glu(OMe)-OMe HCl;MFCD00235872;NSC-83254;1,5-dimethyl 2-aminopentanedioate hydrochloride;H-Glu-(Ome)-Omehydrochloride;SCHEMBL1238805;DTXSID40388975;NSC83254;AR2240;dimethyl (rs)-glutamate hydrochloride;MFCD00266895;AKOS015847816;AKOS015892894;HY-W098059;DS-16144;SY036573;4-DIAZO-4-METHOXYDIPHENYLAMINESULFATE;CS-0150701;D3305;FT-0627830;FT-0654147;FT-0686507;FT-0705575;DL-Glutamic Acid Dimethyl Ester Hydrochloride;EN300-296312;A849968;J-006655;Q27251762;2-AMINO-PENTANEDIOIC ACID DIMETHYL ESTER, HYDROCHLORIDE

Chemical Property of Dimethyl DL-Glutamate Hydrochloride

Chemical Property:

• Appearance/Colour: Crystalline
• Vapor Pressure: 0.0919mmHg at 25°C
• Melting Point: 89-90 °C
• Refractive Index: 26 ° (C=5, H2O)
• Boiling Point: 224.3 °C at 760 mmHg
• Flash Point: 76.7 °C
• PSA: 78.62000
• Density: 1.129 g/cm³
• LogP: 0.94220
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: Methanol, Water
• Water Solubility.: Soluble in water, methanol (50 mg/ml).
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 211.0611356
• Heavy Atom Count: 13
• Complexity: 169

Purity/Quality:

99%, ^*data from raw suppliers

L-Glutamic Acid Dimethyl Ester Hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC(=O)CCC(C(=O)OC)N.Cl
• Uses: L-Glutamic Acid Dimethyl Ester is a diester analogue of L-Glutamic Acid, a non-essential amino acid. L-Glutamic Acid Dimethyl Ester has been shown to antagonize the effects of morphine sulfate. L-Glutamic acid dimethyl ester hydrochloride is used as a pharmaceutical intermediate.

Technology Process of Dimethyl DL-Glutamate Hydrochloride

There total 12 articles about Dimethyl DL-Glutamate Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → L-glutamic dimethyl ester hydrochloride (23150-65-4)

Guidance literature:

methanol; With thionyl chloride; at 0 ℃; for 0.5h;

L-glutamic acid; at 21 ℃; for 72h; Inert atmosphere;

Reference yield: 100.0%

chloro-trimethyl-silane (75-77-4) + L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → L-glutamic dimethyl ester hydrochloride (23150-65-4)

Guidance literature:

In methanol; at 20 ℃; for 16h;

DOI:10.1016/S0040-4020(01)01212-1

Reference yield: 100.0%

methanol (67-56-1) + D-Glutamic acid (6893-26-1,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → D-glutamic acid dimethyl ester hydrochloride (13515-99-6,23150-65-4,27025-25-8)

Guidance literature:

With chloro-trimethyl-silane; at 20 ℃; for 16h;

DOI:10.1016/j.bmc.2008.01.004

upstream raw materials:

methanol

Glutamic acid

L-glutamic acid

L-glutamic acid 5-methyl ester

Downstream raw materials:

N-(N-benzoyl-glycyl)-glutamic acid dimethyl ester

N-{4-[(2-oxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-glutamic acid dimethyl ester

N-{4-[(2-thioxo-benzothiazol-3-ylmethyl)-amino]-benzoyl}-glutamic acid dimethyl ester

C₁₆H₂₀N₂O₇S

Refernces

• 1、 Ghalehshahi, Hajar Golshadi,Balalaie, Saeed,Aliahmadi, Atousa,Moghimi, Roya. "Synthesis of 4-N-α-coumaryl amino acids and investigation of their antioxidant, antimicrobial activities and fluorescence spectra". . p. 1461 - 1470. Retrieved 2018.
• 2、 Cho, Soohyeon,Gu, Lina,In, Ik Joon,Kim, Hakwon,Koo, Sangho,Lee, Taehoon,Wu, Bo. "Ribose conversion with amino acids into pyrraline platform chemicals-expeditious synthesis of diverse pyrrole-fused alkaloid compounds". . p. 31511 - 31525. Retrieved 2021/11/30.
• 3、 Khan, Muhammad T.,Nadeem, Humaira,Khan, Arif-ullah,Abbas, Muzaffar,Arif, Muazzam,Malik, Nadia Shamshad,Malik, Zulkifal,Javed, Ibrahim. "Amino acid conjugates of 2-mercaptobenzimidazole provide better anti-inflammatory pharmacology and improved toxicity profile". . p. 1057 - 1072. Retrieved 2020/08/13.